The Association between Velocity of the Center of Closest Proximity on Subchondral Bones and Osteoarthritis Progression
The Association between Velocity of the Center of Closest Proximity on Subchondral Bones and Osteoarthritis Progression
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DOI：
10.1002/jor.20702
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发表时间：
2009-01-01
影响因子：
2.8
通讯作者：
Tashman, Scott
中科院分区：
文献类型：
--
作者：
Anderst, William J.;Tashman, Scott
关节不稳定后改变的表面相互作用可能会对关节软骨造成新的损伤。本研究测量了正常和不稳定犬膝关节在跑步过程中股骨和胫骨软骨下骨表面最近邻中心的速度。目的：探讨软骨下骨最近邻中心运动速度与软骨损伤程度的关系。动态双平面X线摄影被用来获得连续膝关节运动学[5对照，18颅交叉韧带（CCL）缺陷]在跑步机运行超过2年。定制软件计算股骨上最接近中心相对于股骨骨表面平移的速率与胫骨上最接近中心相对于胫骨骨表面平移的速率之间的差异。比较了2年内发生轻微内侧间室软骨损伤与严重内侧间室软骨损伤的犬。严重损伤犬在CCL处理后2、4和6个月，股骨和胫骨内侧隔室最接近点速度从爪击瞬间到峰值速度差的差异显著增加。这意味着关节运动（犁耕）期间与压缩软骨区域的速度相关的切向力增加可能是引发骨关节炎（OA）发展并驱动OA进展的机制。在未来，关节面速度测量可能有助于识别由于关节不稳定而有长期OA风险的患者。(C)2008骨科研究学会。由威利期刊公司出版J Orthop Res 27：71-77，2009
Altered surface interactions following joint instability may apply novel, damaging leads to articular cartilage. This study measured the velocity of the centers of closest proximity on subchondral bone surfaces on the femur and tibia during running in normal and unstable canine stifle (knee) joints. The purpose was to explore the relationship between the velocity of the centers of closest proximity on subchondral bones and the severity of cartilage damage. Dynamic biplane radiography was used to acquire serial knee kinematics [5 control, 18 cranial cruciate ligament (CCL) deficient] during treadmill running over 2 years. Custom software calculated the difference between the rate at which the center of closest proximity on the femur translated relative to the femur bone surface and the rate at which the center of closest proximity on the tibia translated relative to the tibia bone surface. Comparisons were made between dogs that developed minor versus major medial compartment cartilage damage over 2 years. Major damage dogs showed a significantly greater increase in the difference between femur and tibia medial compartment closest proximity point velocity from the instant of paw strike to peak velocity difference at 2, 4, and 6 months after CCL transaction. This implies increased tangential forces associated with the velocity of the compressed cartilage region during joint movement (plowing) may be a mechanism that initiates osteoarthritis (OA) development and drives OA progression. In the future, articulating surface velocity measurements may be useful to identify patients at risk for long-term OA due to joint instability. (C) 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:71-77, 2009