Newly Explored Faecalibacterium Diversity Is Connected to Age, Lifestyle, Geography, and Disease
Newly Explored Faecalibacterium Diversity Is Connected to Age, Lifestyle, Geography, and Disease
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DOI：
10.1016/j.cub.2020.09.063
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发表时间：
2020-12-21
期刊：
影响因子：
9.2
通讯作者：
Ercolini, Danilo
中科院分区：
文献类型：
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作者：
De Filippis, Francesca;Pasolli, Edoardo;Ercolini, Danilo
粪杆菌在人类肠道中普遍存在，是开发下一代益生菌 (NGP) 或生物治疗药物的一种有前景的微生物。通过分析参考粪杆菌基因组和从 7,907 个人类和 203 个非人类灵长类肠道宏基因组重建的近 3,000 个类粪杆菌宏基因组组装基因组 (MAG)，我们发现了 22 个不同的类粪杆菌物种级基因组 (SGB) 的存在，其中一些根据主题进一步分为不同的菌株 地理起源。 12 种 SGB 在人类肠道中广泛分布，在利用复杂多糖方面表现出不同的基因组潜力，这表明较高的 SGB 多样性可能与植物性食品利用率的增加有关。此外，同一受试者中可能同时出现多达 11 种不同的物种，西方人群的多样性较低，肠道炎症状态和肥胖也是如此。新探索的粪杆菌多样性将能够支持选择适合作为 NGP 的菌株，并考虑其功能潜力中存在的差异。
Faecalibacterium is prevalent in the human gut and a promising microbe for the development of next-generation probiotics (NGPs) or biotherapeutics. Analyzing reference Faecalibacterium genomes and almost 3,000 Faecalibacterium-like metagenome-assembled genomes (MAGs) reconstructed from 7,907 human and 203 non-human primate gut metagenomes, we identified the presence of 22 different Faecalibacterium-like species-level genome bins (SGBs), some further divided in different strains according to the subject geographical origin. Twelve SGBs are globally spread in the human gut and show different genomic potential in the utilization of complex polysaccharides, suggesting that higher SGB diversity may be related with increased utilization of plant-based foods. Moreover, up to 11 different species may co-occur in the same subject, with lower diversity in Western populations, as well as intestinal inflammatory states and obesity. The newly explored Faecalibacterium diversity will be able to support the choice of strains suitable as NGPs, guided by the consideration of the differences existing in their functional potential.