QTL analysis for carcass composition and meat quality traits on SSC7q1.1-q1.4 region in Large White × Meishan F2 pigs.
QTL analysis for carcass composition and meat quality traits on SSC7q1.1-q1.4 region in Large White × Meishan F2 pigs.
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DOI：
10.17221/5963-cjas
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发表时间：
2018-02
影响因子：
1.2
通讯作者：
W. Huang;Z. Xu;Y. Xiong;B. Zuo
中科院分区：
文献类型：
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作者：
W. Huang;Z. Xu;Y. Xiong;B. Zuo
在不同来源的梅山猪资源群体中，均检测到与猪胴体品质和肉质性状相关的QTL，其中q1.1-q1.4区域的QTL最为显著。为了进一步确定和缩小该区域的QTL定位范围，本研究利用8个基因（BTNL 1、SLC 39 A7、COL 21 A1、PPARD、GLP 1 R、MDFI、GNMT和PLA 2G 7）的7个单核苷酸多态性（SNPs）和1个插入或缺失位点，以及2个侧翼微卫星标记（SW 2155和SW 352）对大白色×梅山资源群体进行了连锁定位。共检测到10个染色体显著性QTL和2个提示性QTL，将影响胴体重和屠宰率的QTL定位在BTNL 1和SLC 39 A7区间内。皮重和胴体率、骨重和胴体率的QTL位于PPARD和GLP 1 R之间。在GNMT和PLA 2G 7基因之间检测到了控制脂肪重和胴体率的QTL，在GLP 1 R和MDFI基因之间检测到了控制里脊肌宽的QTL。本研究结果将有助于鉴定该地区致病的分子遗传变异。
Significant QTL for carcass and meat quality traits on Sus scrofa chromosome 7 (SSC7) were detected in various Meishan derived resource populations, especially on q1.1-q1.4 region. In order to confirm and narrow the QTL in this region, seven single-nucleotide polymorphisms (SNPs) and one insertion or deletion located in eight genes (BTNL1 , SLC39A7, COL21A1, PPARD, GLP1R, MDFI, GNMT, and PLA2G7) were included for linkage mapping in a Large White × Meishan resource population, as well as two flanking microsatellite markers (SW2155 and SW352). Ten chromosome-wise significant QTL and two suggestive QTL were found. QTL affecting carcass weight and dressing percentage were mapped within the interval BTNL1 and SLC39A7. QTL for skin weight and percentage, bone weight and percentage in carcass were located between the interval PPARD and GLP1R. QTL for fat weight and percentage in carcass were detected between GNMT and PLA2G7 genes, while QTL for loin muscle width was found between GLP1R and MDFI. The results of this study will help to facilitate identifying the causative molecular genetic variation in this region.