Normal limits for left ventricular ejection fraction and volumes estimated with gated myocardial perfusion imaging in patients with normal exercise test results: Influence of tracer, gender, and acquisition camera
Normal limits for left ventricular ejection fraction and volumes estimated with gated myocardial perfusion imaging in patients with normal exercise test results: Influence of tracer, gender, and acquisition camera
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DOI：
10.1067/mnc.2000.109861
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发表时间：
2000-11-01
影响因子：
2.4
通讯作者：
Bergmann, SR
中科院分区：
文献类型：
--
作者：
Ababneh, AA;Sciacca, RR;Bergmann, SR
背景使用锝-99m sestamibi或铊-201等示踪剂的心肌成像被广泛用作测量心肌灌注的手段。通过门控采集，这些示踪剂还可以用作测量左心室射血分数（EF）以及舒张末期和收缩末期容积（分别为EDV和ESV）的手段。本研究的目的是确定EF、EDV和ESV的正常范围，并评估所使用的示踪剂、患者性别或所使用的采集相机引起的差异。方法和结果。共有1513例连续患者（平均年龄60 ± 12岁[SD]）在布鲁斯运动试验中结果正常，在峰值负荷时注射Tc-99 m sestamibi（n = 884）或Tl-201（n = 629）。尽管所有患者均转诊评价胸痛或呼吸困难，许多患者存在心脏危险因素，但所有患者均具有正常的运动能力（根据年龄校正），无缺血心电图体征，灌注扫描结果正常，通过定量门控单光子发射计算机断层扫描（QGS）确定的室壁运动正常。在3台不同相机中的1台上采集扫描。所有接受门控Tc-99 m sestamibi扫描的患者的平均EF为63% +/-9%，与接受门控Tl-201扫描的患者（63% +/- 9%）无差异。然而，当考虑患者的性别时，女性的平均EF为66% ± 8%，Tc-99 m sestamibi（n = 519）高于男性的平均EF（58% ± 8%，n = 365，P
Background. Myocardial imaging with tracers such as technetium-99m sestamibi or thallium-201 is extensively used as a means of measuring myocardial perfusion. With gated acquisition, these tracers can also be used as a means of measuring left ventricular ejection fraction (EF) and end diastolic and end systolic volumes (EDV and ESV, respectively). The objective of this study was to determine the normal range of EF, EDV, and ESV and to evaluate differences caused by either the tracer used, the gender of the patient, or the acquisition camera used.Methods and Results. A total of 1513 consecutive patients (mean age, 60 +/- 12 years [SD]) who had normal results on Bruce exercise tests had either Tc-99m sestamibi (n = 884) or Tl-201 (n = 629) injected at peak stress. Although all patients were referred for the evaluation of chest pain or dyspnea and many had cardiac risk factors, all had normal exercise capacity corrected for age, no electrocardiographic signs of ischemia, normal results on perfusion scans, and normal wall motion determined by means of quantitated gated single photon emission computed tomography (QGS). Scans were acquired on 1 of 3 different cameras. The mean EF for all patients who had gated Tc-99m sestamibi scans was 63% +/- 9%, not different from patients who had gated Tl-201 scans (63% +/- 9%). However, when the gender of the patient was considered, the mean EF for women was 66% +/- 8% with Tc-99m sestamibi (n = 519), higher than the mean EF for men (58% +/- 8%, n = 365, P