A Neural Network Underlying Circadian Entrainment and Photoperiodic Adjustment of Sleep and Activity in Drosophila
A Neural Network Underlying Circadian Entrainment and Photoperiodic Adjustment of Sleep and Activity in Drosophila
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DOI：
10.1523/jneurosci.0992-16.2016
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发表时间：
2016-08-31
影响因子：
5.3
通讯作者：
Shafer, Orie Thomas
中科院分区：
文献类型：
--
作者：
Schlichting, Matthias;Menegazzi, Pamela;Shafer, Orie Thomas
在动物中，生物钟已经进化到可以协调行为和新陈代谢的时间。一致的计时需要将这些时钟夹带至太阳日，这一过程对于有机体的健康至关重要。光周期是生物钟最重要的外部线索，昼夜节律系统使用多个光感受器将计时与光/暗周期联系起来。来自这些光感受器的光信息如何整合到生物钟神经元网络中以支持夹带尚不清楚。我们的结果表明，HB 孔眼的输入对神经元亚群的生理机能有不同的影响。这种输入途径与来自复眼的输入一起，精确地记录了苍蝇在漫长的夏日里的活动。我们的结果提供了光传导和融入昼夜节律系统的机制模型，识别昼夜节律时钟神经元网络内新的和意想不到的网络图案。
In animals, circadian clocks have evolved to orchestrate the timing of behavior and metabolism. Consistent timing requires the entrainment these clocks to the solar day, a process that is critical for an organism's health. Light cycles are the most important external cue for the entrainment of circadian clocks, and the circadian system uses multiple photoreceptors to link timekeeping to the light/dark cycle. How light information from these photorecptors is integrated into the circadian clock neuron network to support entrainment is not understood. Our results establish that input from the HB eyelets differentially impacts the physiology of neuronal subgroups. This input pathway, together with input from the compound eyes, precisely times the activity of flies under long summer days. Our results provide a mechanistic model of light transduction and integration into the circadian system, identifying new and unexpected network motifs within the circadian clock neuron network.