Detection of Hong Kong 97-like H5N1 influenza viruses from eggs of Vietnamese waterfowl
Detection of Hong Kong 97-like H5N1 influenza viruses from eggs of Vietnamese waterfowl
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DOI：
10.1007/s00705-006-0738-7
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发表时间：
2006-08-01
影响因子：
2.7
通讯作者：
Chen, H.
中科院分区：
文献类型：
--
作者：
Li, Y.;Lin, Z.;Chen, H.
从越南旅客没收的鸭蛋和鹅蛋壳清洗液中分离出三种 H5N1 流感病毒。这些病毒的所有八个基因片段与 1997 年在香港引起家禽和人类暴发的 H5N1 禽流感病毒具有高度序列同一性。动物研究表明，这些分离的病毒能够在小鼠肺部复制，并且可以在鸭子的器官中发现，而不会引起任何临床症状或死亡。然而，这些病毒对鸡具有高致病性。尽管这些最近分离出的香港97型H5N1病毒的来源尚未确定，但在鸭和鹅的蛋壳中检测到的这些病毒表明，这种特殊基因型的H5N1病毒可能在自然界中重新出现，或者可能一直在持续传播。
Three H5N1 influenza viruses were isolated from shell washes of duck and goose eggs confiscated from travelers coming from Vietnam. All eight gene segments of these viruses share high sequence identity with the H5N1 avian influenza viruses that caused outbreaks in poultry and humans in Hong Kong in 1997. Animal studies indicate that these isolated viruses are able to replicate in mouse lung and could be found in the organs of ducks without causing any clinical signs or death. However, the viruses are highly pathogenic for chickens. Although the source of these recently isolated Hong Kong 97-like H5N1 viruses is undetermined, their detection in the egg shell of duck and goose suggests that this particular genotype of H5N1 virus may have re-emerged in nature or may have been circulating continuously.