Antiviral mechanism change of poly(styrene sulfonate) through gold nanoparticle coating
Antiviral mechanism change of poly(styrene sulfonate) through gold nanoparticle coating
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DOI：
10.1039/d3py01217d
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发表时间：
2024-02-07
影响因子：
4.6
通讯作者：
Jones，Samuel T.
中科院分区：
文献类型：
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作者：
Bhebhe，Lorraine M.;Kim，Jungyeon;Jones，Samuel T.
病毒是能够引起严重全球健康问题的病原体，因此制定针对病毒的干预措施至关重要。设计广谱抗病毒药物的一种策略是通过模拟细胞表面的磺化糖聚合物，以便抗病毒材料抑制病毒粒子/细胞相互作用。人们已经研究了许多天然和合成聚合物，然而，大多数都显示出可逆且非破坏性的病毒抑制机制。在此，我们提出了一种通过将先前已知的病毒抑制聚合物聚（苯乙烯磺酸盐）附着到金纳米颗粒上来获得杀病毒材料的简便途径。我们证明，通过改变大分子结构，可以改变聚合物的作用模式，同时保持其低 IC50。
Viruses are pathogens capable of causing serious global health problems and therefore the development of interventions against them is of paramount importance. One strategy towards designing broad-spectrum antivirals is through the mimicking of sulfonated glycopolymers on the cell surface so that the virion/cell interaction is inhibited by the antiviral material. A number of natural and synthetic polymers have been investigated, however, most show a virustatic mechanism, which is reversible and non-destructive. Herein we present a facile route to virucidal materials by attaching a previously known virustatic polymer, poly(styrene sulfonate), onto gold nanoparticles. We show that it is possible to alter the polymer's mode of action whilst maintaining its low IC50 by changing the macromolecular architecture.