Polyol recognition in catalysis: Toward selective modification of glycosylated polypeptides with boronic acid-rhodium(II) catalysts
Polyol recognition in catalysis: Toward selective modification of glycosylated polypeptides with boronic acid-rhodium(II) catalysts
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催化中的多元醇识别：用硼酸-铑(II)催化剂选择性修饰糖基化多肽
DOI：
10.1039/d3cc03371f
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发表时间：
2023
影响因子：
4.9
通讯作者：
Ball, Zachary Thomas
中科院分区：
文献类型：
--
作者：
Vargas, Reyner D.;Ding, Yuxuan;Trial, Hallie O.;Qian, Ruoyu;Ball, Zachary Thomas
已经开发了用于肽和蛋白质修饰的邻近诱导方法，其使用识别元件如抑制剂、抗体或氨基酸上的亲和标签。然而，对化学修饰的识别仍然没有得到广泛的探索。探索硼酸及其衍生物的研究已经显示出它们作为选择性分子识别元件的诱人能力，在这项研究中，我们描述了这些想法的应用发现的催化邻近诱导的方法，用于共价修饰的糖肽使用硼酸作为糖识别元件。
Proximity-induced methodologies for peptide and protein modification have been developed using recognition elements like inhibitors, antibodies, or affinity tags on amino acids. However, the recognition of saccharides for chemical modification remains widely unexplored. Studies exploring boronic acids and their derivatives have shown their alluring capabilities as selective molecular recognition elements for saccharides, and in this study we describe the application of these ideas to the discovery of a catalytic proximity-induced methodology for covalent modification of glycopeptides using boronic acids as a saccharide recognition element.