Layer-specific network oscillation and spatiotemporal receptive field in the visual cortex
Layer-specific network oscillation and spatiotemporal receptive field in the visual cortex
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DOI：
10.1073/pnas.0903962106
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发表时间：
2009-10-20
影响因子：
11.1
通讯作者：
Dan, Yang
中科院分区：
文献类型：
--
作者：
Sun, Wenzhi;Dan, Yang
新皮质的一个典型特征是其层状组织，表征不同层的活动模式是理解皮质处理的重要一步。利用大鼠视觉皮层的体内全细胞记录，我们发现锥体神经元持续突触输入的时间模式表现出明显的层状特异性。虽然低频（类似于 2 Hz）活动在第 2/3 层 (L2/3) 中被广泛观察到，但窄带快速振荡 (10-15 Hz) 在第 5 层 (L5) 中很突出。这种快速振荡仅由兴奋性输入来承载。此外，持续活动的频率与视觉整合的时空窗口密切相关：具有快速振荡自发输入的神经元表现出短暂的视觉反应和较小的感受野（RF），而那些具有缓慢输入的神经元则表现出长时间的反应和较大的RF。这些发现表明，每一层内视觉信息的神经表示受到自发活动中表现的局部网络的时间动态的强烈影响。
A quintessential feature of the neocortex is its laminar organization, and characterizing the activity patterns in different layers is an important step in understanding cortical processing. Using in vivo whole-cell recordings in rat visual cortex, we show that the temporal patterns of ongoing synaptic inputs to pyramidal neurons exhibit clear laminar specificity. Although low-frequency (similar to 2 Hz) activity is widely observed in layer 2/3 (L2/3), a narrow-band fast oscillation (10-15 Hz) is prominent in layer 5 (L5). This fast oscillation is carried exclusively by excitatory inputs. Moreover, the frequency of ongoing activity is strongly correlated with the spatiotemporal window of visual integration: Neurons with fast-oscillating spontaneous inputs exhibit transient visual responses and small receptive fields (RFs), whereas those with slow inputs show prolonged responses and large RFs. These findings suggest that the neural representation of visual information within each layer is strongly influenced by the temporal dynamics of the local network manifest in spontaneous activity.