Maximum Likelihood and the Single Receptor
Maximum Likelihood and the Single Receptor
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DOI：
10.1103/physrevlett.103.158101
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发表时间：
2009-10-09
影响因子：
8.6
通讯作者：
Wingreen, Ned S.
中科院分区：
文献类型：
--
作者：
Endres, Robert G.;Wingreen, Ned S.
生物细胞感知化学浓度的准确性最终受到粒子通过扩散随机到达受体的限制。这个基本的物理极限通常被认为是Berg-Purcell极限[Biophys. J. 20，193（1977）]。在这里，我们通过将最大似然法应用于受体占有率的时间序列来获得下限。增加的准确度源于仅考虑未占用的时间间隔-忽略占用的时间间隔，因为这些时间间隔不包含关于外部颗粒浓度的任何信息，并且仅降低浓度估计的准确度。最小化约束时间间隔的受体实现了最高的可能精度。我们讨论了细胞如何通过吸收或降解结合粒子来实现这种最佳的传感策略。
The accuracy by which biological cells sense chemical concentration is ultimately limited by the random arrival of particles at the receptors by diffusion. This fundamental physical limit is generally considered to be the Berg-Purcell limit [Biophys. J. 20, 193 (1977)]. Here we derive a lower limit by applying maximum likelihood to the time series of receptor occupancy. The increased accuracy stems from solely considering the unoccupied time intervals-disregarding the occupied time intervals as these do not contain any information about the external particle concentration, and only decrease the accuracy of the concentration estimate. Receptors which minimize the bound time intervals achieve the highest possible accuracy. We discuss how a cell could implement such an optimal sensing strategy by absorbing or degrading bound particles.