Novel Inorganic Nanomaterial-Based Therapy for Bone Tissue Regeneration.
Novel Inorganic Nanomaterial-Based Therapy for Bone Tissue Regeneration.
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基于无机纳米材料的新型骨组织再生疗法
DOI：
10.3390/nano11030789
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发表时间：
2021-03-19
期刊：
影响因子：
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通讯作者：
Liu Y
中科院分区：
文献类型：
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作者：
Fu Y;Cui S;Luo D;Liu Y
广泛的骨缺损修复仍然是一个临床挑战，因为理想的可植入支架需要整合良好的生物相容性，足够的机械强度和高生物活性以支持骨再生。无机纳米材料因其优异的力学性能、可调节的生物界面和多样化的功能而具有重要意义。钙磷化合物、二氧化硅和金属基材料是骨缺损修复中最常见的无机纳米材料类别。纳米羟基磷灰石具有与天然骨磷灰石矿物相似的理化和生物活性，是生物矿化领域研究最多的一类矿物。纳米二氧化硅通过生物硅矿化过程实现类骨的等级结构，仿生硅化可以刺激成骨细胞的成骨活性，同时抑制破骨细胞的分化。新型金属纳米材料，包括钛、镁、锌及其合金，具有显著的强度和应力吸收能力，可以克服聚合物基材料力学性能低和生物陶瓷脆性大的缺点。此外，金属纳米材料的生物可降解性、抗菌活性和干细胞诱导性可以促进骨再生。本文综述了新型无机纳米材料治疗骨缺损的优势，为今后开发新的骨再生策略奠定了基础。
Extensive bone defect repair remains a clinical challenge, since ideal implantable scaffolds require the integration of excellent biocompatibility, sufficient mechanical strength and high biological activity to support bone regeneration. The inorganic nanomaterial-based therapy is of great significance due to their excellent mechanical properties, adjustable biological interface and diversified functions. Calcium–phosphorus compounds, silica and metal-based materials are the most common categories of inorganic nanomaterials for bone defect repairing. Nano hydroxyapatites, similar to natural bone apatite minerals in terms of physiochemical and biological activities, are the most widely studied in the field of biomineralization. Nano silica could realize the bone-like hierarchical structure through biosilica mineralization process, and biomimetic silicifications could stimulate osteoblast activity for bone formation and also inhibit osteoclast differentiation. Novel metallic nanomaterials, including Ti, Mg, Zn and alloys, possess remarkable strength and stress absorption capacity, which could overcome the drawbacks of low mechanical properties of polymer-based materials and the brittleness of bioceramics. Moreover, the biodegradability, antibacterial activity and stem cell inducibility of metal nanomaterials can promote bone regeneration. In this review, the advantages of the novel inorganic nanomaterial-based therapy are summarized, laying the foundation for the development of novel bone regeneration strategies in future.
负载聚DL-乳酸-乙醇酸共聚物微球中介孔二氧化硅和羟基磷灰石对骨缺损再生的协同作用
影响因子：
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作者：
He S;Lin KF;Fan JJ;Hu G;Dong X;Zhao YN;Song Y;Guo ZS;Bi L;Liu J
通讯作者：
Liu J