A randomized controlled trial of adjunctive family therapy and treatment as usual following inpatient treatment for anorexia nervosa adolescents.
A randomized controlled trial of adjunctive family therapy and treatment as usual following inpatient treatment for anorexia nervosa adolescents.
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DOI：
10.1371/journal.pone.0028249
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Jeammet P
中科院分区：
文献类型：
--
作者：
Godart N;Berthoz S;Curt F;Perdereau F;Rein Z;Wallier J;Horreard AS;Kaganski I;Lucet R;Atger F;Corcos M;Fermanian J;Falissard B;Flament M;Eisler I;Jeammet P
神经性厌食症（AN）的治疗研究很少。虽然在AN治疗的“真实的世界实践”中使用的大多数治疗方案诉诸于多学科方法，但很少对其进行评价。比较两种针对青少年重度AN的多维住院后门诊治疗方案：家庭治疗（TAU）与家庭治疗加家庭治疗（TAU+FT）。从1999年至2002年招募了60名年龄在13至19岁的女性AN青少年，并在2004年进行了18个月的随访。随机分配至两个治疗组之一（每组30例）。TAU计划包括单独为患者进行的会议以及为患者及其父母与精神科医生进行的会议。TAU+FT计划与通常的计划相同，但也包括针对家庭内部动力学的家庭治疗课程，但不包括饮食失调症状。主要的结局指标是Morgan和Russell结局类别（良好或中等与不良结局）。次要结果指标包括AN症状或其后果（进食症状、体重指数、闭经、随访期间住院次数、社会适应）。评价者（而非参与者）对随机化设盲。在18个月随访时，我们发现Morgan和Russell结局类别的显著组效应有利于家庭治疗方案（意向治疗：TAU+FT：12/30（40%）; TAU：5/29（17.2%）p = 0.05;符合方案分析：分别为12/26（46.2%）; 4/27（14.8%），p = 0.01）。 在达到健康体重方面观察到类似的组效应（即，BMI≥第10百分位数）和月经状态。增加家庭治疗课程，重点是家庭内部的动态，而不是吃维生素A，以一个多方面的计划，提高了严重的AN女孩的治疗效果。Controlled-trials.com www.example.com
Research on treatments in anorexia nervosa (AN) is scarce. Although most of the therapeutic programs used in ‘real world practice’ in AN treatment resort to multidisciplinary approaches, they have rarely been evaluated. To compare two multidimensional post-hospitalization outpatients treatment programs for adolescents with severe AN: Treatment as Usual (TAU) versus this treatment plus family therapy (TAU+FT). Sixty female AN adolescents, aged 13 to 19 years, were included in a randomized parallel controlled trial conducted from 1999 to 2002 for the recruitment, and until 2004 for the 18 months follow-up. Allocation to one of the two treatment groups (30 in each arm) was randomised. The TAU program included sessions for the patient alone as well as sessions with a psychiatrist for the patient and her parents. The TAU+FT program was identical to the usual one but also included family therapy sessions targeting intra-familial dynamics, but not eating disorder symptoms. The main Outcome Measure was the Morgan and Russell outcome category (Good or Intermediate versus Poor outcome). Secondary outcome indicators included AN symptoms or their consequences (eating symptoms, body mass index, amenorrhea, number of hospitalizations in the course of follow-up, social adjustment). The evaluators, but not participants, were blind to randomization. At 18 months follow-up, we found a significant group effect for the Morgan and Russell outcome category in favor of the program with family therapy (Intention-to-treat: TAU+FT :12/30 (40%); TAU : 5/29 (17.2%) p = 0.05; Per Protocol analysis: respectively 12/26 (46.2%); 4/27 (14.8%), p = 0.01). Similar group effects were observed in terms of achievement of a healthy weight (i.e., BMI≥10th percentile) and menstrual status. Adding family therapy sessions, focusing on intra-familial dynamics rather than eating symptomatology, to a multidimensional program improves treatment effectiveness in girls with severe AN. Controlled-trials.com ISRCTN71142875
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影响因子：
3.3
作者：
Ball, Jillian;Mitchell, Philip
通讯作者：
Mitchell, Philip
影响因子：
--
作者：
Halmi, KA;Agras, WS;Kraemer, HC
通讯作者：
Kraemer, HC
DOI：
10.1007/bf03325114
发表时间：
2009-12-01
影响因子：
2.9
作者：
Godart, N.;Wallier, J.;Jeammet, P.
通讯作者：
Jeammet, P.
影响因子：
10.5
作者：
Gowers, SG;Weetman, J;Elvins, R
通讯作者：
Elvins, R
影响因子：
1.8
作者：
Godart, N;Perdereau, F;Jeammet, R
通讯作者：
Jeammet, R