Nuclear Coregulatory Complexes in Tregs as Targets to Promote Anticancer Immune Responses.
Nuclear Coregulatory Complexes in Tregs as Targets to Promote Anticancer Immune Responses.
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DOI：
10.3389/fimmu.2022.909816
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发表时间：
2022
影响因子：
7.3
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中科院分区：
文献类型：
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调节性T细胞（Treg）在对各种癌症的反应中表现出相当大的异质性。这种细胞类型之间的功能差异受到控制其基因表达的多蛋白核复合物的严重影响。许多这样的复合物通过改变对Treg功能重要的基因（包括叉头P3（Foxp 3）转录因子）的表观遗传谱来机械地起作用。与组蛋白/蛋白脱乙酰酶（HDAC）类酶的某些成员（如HDAC 1、2和3）形成的复合物沿着组蛋白甲基转移酶复合物，在Foxp 3和Treg身份的诱导和稳定中是重要的。循环和肿瘤内THBE的功能行为极大地影响抗肿瘤免疫应答，并且可以预测患者的结局。因此，靶向这些调节复合物在Tclad内可能具有治疗潜力，特别是在个性化免疫疗法中。
T-regulatory (Treg) cells display considerable heterogeneity in their responses to various cancers. The functional differences among this cell type are heavily influenced by multiprotein nuclear complexes that control their gene expression. Many such complexes act mechanistically by altering epigenetic profiles of genes important to Treg function, including the forkhead P3 (Foxp3) transcription factor. Complexes that form with certain members of the histone/protein deacetylase (HDAC) class of enzymes, like HDACs 1, 2, and 3, along with histone methyltransferase complexes, are important in the induction and stabilization of Foxp3 and Treg identity. The functional behavior of both circulating and intratumoral Tregs greatly impacts the antitumor immune response and can be predictive of patient outcome. Thus, targeting these regulatory complexes within Tregs may have therapeutic potential, especially in personalized immunotherapies.