RECONSTITUTION OF SPINAL CORD AFTER ABLATION IN ADULT TRITURUS
RECONSTITUTION OF SPINAL CORD AFTER ABLATION IN ADULT TRITURUS
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DOI：
10.1016/0012-1606(67)90038-3
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发表时间：
1967-01-01
影响因子：
2.7
通讯作者：
WARD, MB
中科院分区：
文献类型：
--
作者：
BUTLER, EG;WARD, MB
在对成年毒降三角犬和pyrrhogaster的臂后区域脊髓进行2-4 mm的消融后，研究了脊髓重建的机制和消融后运动活动的恢复。采用了电影记录和直接观察。出现游泳企图的平均时间为消融后76天；成功游泳的平均时间为89天。正常的游泳力量从未完全恢复在成年三角鱼，因为它是在幼虫Ambystoma。脊髓的重建是由每个横断面愈合开始的，随后是中央椎管的扩张，形成一个细长的末端囊泡。从每个末端囊泡壁生长出来的神经纤维数量最终与对面囊泡壁结合，建立神经纤维桥。在许多情况下，光纤桥在烧蚀间隙上定向在一个直接的过程中。在其他情况下，1个或多个神经纤维桥位于消融间隙和椎管范围之外的异常位置。不管它们的数量和位置如何，神经纤维桥最终在重建的脊髓白质中形成功能性的纵向束。神经元对消融间隙的重新填充以及由此引起的灰质重构似乎是细胞迁移和增殖的结果。讨论了似乎涉及的移徙活动的类型。
After ablation of 2-4 mm of the spinal cord in the postbrachial region of the adult Triturus viridescens and T. pyrrhogaster, the mechanics of reconstitution of the cord and the return of locomotor activities posterior to the ablation level were studied. Cinematographic records and direct observations were used. The average time for appearance of attempts to swim was 76 days post-ablation; successful swimming occurred at an average of 89 days. Normal swimming strength was never completely regained in the adult Triturus as it was in larval Ambystoma. Reconstitution of the spinal cord is initiated by healing at each transection surface followed shortly by dilation of the central canal to form an elongated terminal vesicle. Numbers of nerve fibers growing out from the wall of each terminal vesicle ultimately unit with the wall of the opposite vesicle to establish nerve fiber bridges. In many cases, fiber bridges are oriented in a direct course across the ablation gap. In other instances, 1 or more nerve fiber bridges occupy aberrent positions well outside the limits of the ablation gap and vertebral canal. Regardless of their number or positions, nerve fiber bridges eventually form functional longitudinal tracts of the reconstituted white matter of the spinal cord. Repopula-tion of the ablation gap by neurons and the consequent reconstitution of the gray matter appears to result from both cell migration and proliferation. The types of migratory activities which appear to be involved are discussed.