Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells.
Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells.
复制标题
谷胱甘肽消耗可逆转小鼠 L1210 白血病细胞的顺铂耐药性。
DOI：
10.1016/0304-3835(87)90067-x
复制
发表时间：
1987
期刊：
影响因子：
9.7
通讯作者：
Burns,CP
中科院分区：
文献类型：
--
作者：
Hromas,RA;Andrews,PA;Murphy,MP;Burns,CP
对广泛使用的顺铂获得性耐药的机制知之甚少。顺铂耐药小鼠白血病L1210细胞系L1210 PAM与其敏感的亲本细胞系L1210/PAM相比，具有升高的细胞谷胱甘肽含量。L，l-丁硫氨酸-S，R-亚砜亚胺使L 1210 PAM细胞的谷胱甘肽含量降低到接近L 1210/PAM细胞的水平，并消除了对顺铂的耐药性。
Little is understood about the mechanism of acquired resistance to the widely used antineoplastic drug, cisplatin. The cisplatin-resistant murine leukemia L1210 cell line L 1210 PAM has an elevated cellular glutathione content, as compared to its sensitive parent cell line, L1210/∗. Exposure to d, l-buthionine-S, R-sulfoximine reduced L 1210 PAM cells' glutathione content to nearly that of L1210/∗ cells and abrogated the resistance to cisplatin.