Control of synthesis and secretion of intestinal apolipoprotein A-IV by lipid.
Control of synthesis and secretion of intestinal apolipoprotein A-IV by lipid.
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DOI：
10.1093/jn/127.3.537s
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发表时间：
1997-03
期刊：
影响因子：
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通讯作者：
T. Kalogeris;Maria-Dolores Rodríguez;P. Tso
中科院分区：
文献类型：
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作者：
T. Kalogeris;Maria-Dolores Rodríguez;P. Tso
载脂蛋白（apo） a - iv是一种富含三酰甘油的肠分泌脂蛋白，最近被认为是胃功能和食物摄入的生理控制者。因此，了解apo A-IV的表达、合成和分泌的控制机制是很重要的。载脂蛋白a - iv是一个紧密相连的多基因簇的成员，其中包括载脂蛋白a - i和C-III。载脂蛋白A-IV的表达和合成在物种、组织、发育阶段和激素反应方面表现出明显的差异性，但肠道载脂蛋白A-IV始终受到膳食脂质的刺激。载脂蛋白A-IV对脂质反应的精确分子机制尚未明确定义。大多数证据支持这样的假设，即脂质转运的某些方面是载脂蛋白a - iv反应所必需的，但这种反应只有一部分可能是由于肠道脂质的直接作用：最近的研究结果表明，肠道载脂蛋白a - iv的产生与“回肠制动器”操作相关的激素和/或神经因素之间存在联系。因此，载脂蛋白A-IV可能在上胃肠道功能和摄食行为的调节中发挥综合作用。
Apolipoprotein (apo) A-IV, a component of intestinally secreted, triacylglycerol-rich lipoproteins, has recently been proposed as a physiological controller of gastric function and food intake. Thus, it is important to understand the mechanisms involved in the control of expression, synthesis and secretion of apo A-IV. Apo A-IV is a member of a closely linked, multigene cluster which includes apolipoproteins A-I and C-III. Expression and synthesis of apo A-IV display marked variability with regard to species, tissue, stage of development and response to hormones, but intestinal apo A-IV is consistently stimulated by dietary lipid. The precise molecular mechanisms underlying the response of apo A-IV to lipid have not been clearly defined. Most evidence supports the hypothesis that some aspect of lipid transport is necessary for the apo A-IV response, but only part of this response may be due to a direct effect of intestinal lipid: recent findings suggest a connection between intestinal production of apo A-IV and hormonal and/or neural factors associated with operation of the "ileal brake." Thus, apo A-IV may play an integrative role in the modulation of both upper gastrointestinal function and ingestive behavior.