Androgen-responsive circular RNA circSMARCA5 is up -regulated and promotes cell proliferation in prostate cancer
Androgen-responsive circular RNA circSMARCA5 is up -regulated and promotes cell proliferation in prostate cancer
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雄激素响应性环状RNA circSMARCA5上调并促进前列腺癌细胞增殖
DOI：
10.1016/j.bbrc.2017.07.162
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发表时间：
2017-11-25
影响因子：
3.1
通讯作者：
Li, Yao
中科院分区：
文献类型：
--
作者：
Kong, Zhe;Wan, Xuechao;Li, Yao
Prostate cancer (PCa) is one of the most commonly diagnosed cancers in males worldwide. Circular RNA (circRNA) is a unique class of RNA transcribed by RNA polymerase II characterized by jointing 3' and 5' ends together via exon or intron circularization. However, the molecular functions of circRNAs in prostate cancer have rarely been explored. In present study, we found circ-SMARCA5 was up-regulated in prostate cancer samples compared to match normal tissues. We also observed circ-SMARCA5 expression was significantly induced after DHT treatment. Functional experiments showed circ-SMARCA5 acted as an oncogene in prostate cancer by promoting cell cycle and inhibiting cell apoptosis. We thought this study provided useful information for exploring circRNAs as potential therapeutic and prognostic targets for prostate cancer. (C) 2017 Published by Elsevier Inc.
