Alternative sources of pluripotent stem cells: scientific solutions to an ethical dilemma.
Alternative sources of pluripotent stem cells: scientific solutions to an ethical dilemma.
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DOI：
10.1089/scd.2008.0013
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发表时间：
2008-02
影响因子：
4
通讯作者：
M. Rao;M. Condic
中科院分区：
文献类型：
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作者：
M. Rao;M. Condic
由于多种因素，美国的干细胞研究人员面临着不确定性的泥潭：使用胚胎进行研究的伦理分歧，管理这项研究的联邦指导方针缺乏明确性，围绕新人类胚胎干细胞（HES）细胞系的限制性专利情况;以及有资格获得联邦资助的研究类型的限制。在这篇评论中，我们描述了最近的进展，衍生的人胚胎干细胞样线可能允许至少有一些这些不确定性得到解决。更重要的是，我们认为，通过道德上可接受的方法获得hES细胞样系不仅可以避免对干细胞研究的长期伦理辩论的腐蚀性影响，而且还可以让美国研究人员获得联邦基金，并在更公平的国际竞争环境中竞争。
Stem cell researchers in the United States have faced a quagmire of uncertainty due to multiple factors: the ethical divide over the use of embryos for research, the lack of clarity in federal guidelines governing this research, the restrictive patent situation surrounding the generation of new human embryonic stem (HES) cell lines; and the limits on types of research eligible for federal funding. In this commentary, we describe how recent advances in derivation of hES cell-like lines may allow at least some of these uncertainties to be resolved. More importantly, we suggest that the derivation of hES cell-like lines by morally acceptable methods would not only avoid the corrosive effects of a protracted ethical debate over stem cell research, but would also allow U.S. researchers to access federal funds and compete on a more level international playing field.