Intensity Modulated Proton Therapy Versus Intensity Modulated Photon Radiation Therapy for Oropharyngeal Cancer: First Comparative Results of Patient-Reported Outcomes
Intensity Modulated Proton Therapy Versus Intensity Modulated Photon Radiation Therapy for Oropharyngeal Cancer: First Comparative Results of Patient-Reported Outcomes
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DOI：
10.1016/j.ijrobp.2016.02.044
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发表时间：
2016-07-15
影响因子：
7
通讯作者：
Frank, Steven J.
中科院分区：
文献类型：
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作者：
Sio, Terence T.;Lin, Huei-Kai;Frank, Steven J.
目的：我们假设，与接受调强光子治疗（IMRT）的患者相比，接受调强质子治疗（IMPT）的口咽癌患者的症状负担较低，这是通过患者报告结局（PRO）调查测量的。2006年至2015年，患者通过前瞻性登记研究接受了口咽癌治疗，同时接受化疗和IMPT或化疗，IMRT，并在治疗基线前、治疗期间（急性期）、治疗后前3个月内（亚急性期）和治疗后（慢性期）的不同时间完成MD安德森头颈癌症状量表（MDASI-HN）模块。个体症状和前5名和前11名最严重的症状进行了总结和比较之间的放射治疗models.Results：PRO数据收集和分析35例患者化疗和IMPT和46例化疗和IMRT治疗。两组的基线症状负担相似。总体前5位症状是食物味道问题（0-10量表上的平均评分为4.91）、口干（4.49）、吞咽/咀嚼困难（4.26）、食欲不振（4.08）和疲劳（4.00）。在前11位症状中，亚急性期和慢性期味觉和食欲的变化有利于IMPT（均P
Purpose: We hypothesized that patients with oropharyngeal cancer treated with intensity modulated proton therapy (IMPT) would have lower symptom burdens, as measured by patient-reported outcome (PRO) surveys, than patients treated with intensity modulated photon therapy (IMRT).Methods and Materials: Patients were treated for oropharyngeal cancer from 2006 to 2015 through prospective registries with concurrent chemotherapy and IMPT or chemotherapy and IMRT and completed the MD Anderson Symptom Inventory for Head and Neck Cancer (MDASI-HN) module at various times before treatment baseline), during treatment (acute phase), within the first 3 months after treatment (subacute phase), and afterward (chronic phase). Individual symptoms and the top 5 and top 11 most severe symptoms were summarized and compared between the radiation therapy modalities.Results: PRO data were collected and analyzed from 35 patients treated with chemotherapy and IMPT and from 46 treated with chemotherapy and IMRT. The baseline symptom burdens were similar between both groups. The overall top 5 symptoms were food taste problems (mean score 4.91 on a 0-10 scale), dry mouth (4.49), swallowing/chewing difficulties (4.26), lack of appetite (4.08), and fatigue (4.00). Among the top 11 symptoms, changes in taste and appetite during the subacute and chronic phases favored IMPT (all P