Association of plasma concentrations of branched-chain amino acids with risk of colorectal adenoma in a large Japanese population
Association of plasma concentrations of branched-chain amino acids with risk of colorectal adenoma in a large Japanese population
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DOI：
10.1093/annonc/mdw680
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发表时间：
2017-04-01
影响因子：
50.5
通讯作者：
Tsugane, S.
中科院分区：
文献类型：
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作者：
Budhathoki, S.;Iwasaki, M.;Tsugane, S.
工作背景：动物研究的现有证据表明，支链氨基酸（BCAAs）可能对结直肠癌发生具有保护作用。然而，支链氨基酸对结直肠肿瘤的可能作用尚未在人类中进行评估。在这里，我们的目的是评估是否血浆中的支链氨基酸浓度与结直肠腺瘤（CRA），结直肠cancer.Patients和方法的前驱病变的风险：CRA的情况下，控制确定从受检者谁接受全结肠镜检查的一部分，2004年和2005年之间的癌症筛查计划，并回答自我管理的饮食和生活方式问卷。我们测定了629例腺瘤患者和584例对照者的血浆亮氨酸、异亮氨酸和缬氨酸浓度。非条件Logistic回归模型被用来估计比值比（OR）和95%置信区间（CI）之间的关联BCAA和CRA的风险调整后的潜在confounders.Results：高血浆浓度的亮氨酸，缬氨酸和总BCAA与CRA风险呈负相关调整后的潜在confounders. Results。最高与最低四分位数的多变量校正OR分别为亮氨酸0.60（95% CI 0.42-0.87，P趋势= 0.006）、缬氨酸0.68（95% CI 0.48-0.97，P趋势= 0.09）和总BCAA 0.68（95% CI 0.48-0.98，P趋势= 0.10）。按性别进一步分析显示，这种反向关联在男性中明显，但在女性中不明显：亮氨酸、缬氨酸和总支链氨基酸的OR值为0.50（95% CI 0.32-0.80，P趋势= 0.003），0.60（95% CI 0.38-0.95，P趋势= 0.01）和0.58（95% CI 0.37-0.93，P趋势= 0.04），男性和0.78（95% CI 0.42-1.45，P趋势= 0.44），0.77（95% CI 0.41-1.43，P趋势= 0.85）和0.84（95% CI 0.45-1.57，P趋势= 0.81）。我们的研究结果表明，支链氨基酸可能有一个有益的影响，对大肠癌的发生过程中，至少在早期阶段。BCAA和结直肠癌发生之间潜在联系的机制值得进一步研究。
Background: Available evidence from animal studies suggests that branched-chain amino acids (BCAAs) may have a protective effect against colorectal carcinogenesis. However, a possible effect of BCAAs against colorectal neoplasia has not been evaluated in humans. Here, we aimed to evaluate whether plasma concentrations of BCAA are associated with the risk of colorectal adenoma (CRA), a precursor lesion of colorectal cancer.Patients and methods: CRA cases and controls were identified from examinees who underwent total colonoscopy as part of a cancer screening program between 2004 and 2005 and responded to self-administered dietary and lifestyle questionnaires. We measured plasma concentrations of leucine, isoleucine and valine in 629 patients with adenoma and 584 controls. Unconditional logistic regression models were used to estimate odds ratio (OR) and 95% confidence interval (CI) for the association between BCAA and CRA risk after adjustment for potential confounders.Results: High plasma concentrations of leucine, valine and total BCAA were inversely associated with CRA risk after adjustment of potential confounders. The multivariate-adjusted ORs for the highest versus lowest quartiles were 0.60 (95% CI 0.42-0.87, P-trend = 0.006) for leucine, 0.68 (95% CI 0.48-0.97, P-trend = 0.09) for valine and 0.68 (95% CI 0.48-0.98, P-trend = 0.10) for total BCAA. Further analysis by gender revealed that this inverse association was clearly evident in men, but not in women: the corresponding OR for leucine, valine and total BCAA was 0.50 (95% CI 0.32-0.80, P-trend = 0.003), 0.60 (95% CI 0.38-0.95, P-trend = 0.01) and 0.58 (95% CI 0.37-0.93, P-trend = 0.04), respectively, in men and 0.78 (95% CI 0.42-1.45, P-trend = 0.44), 0.77 (95% CI 0.41-1.43, P-trend = 0.85) and 0.84 (95% CI 0.45-1.57, P-trend = 0.81), respectively, in women.Conclusion: Our finding suggests that BCAAs may have a beneficial influence against the process of colorectal carcinogenesis, at least in the early stage. The mechanisms underlying this potential association between BCAA and colorectal carcinogenesis warrant further investigation.