Impact of Oral Antibiotics on Health-related Quality of life after Mandibular Third Molar Surgery: An Observational Study
Impact of Oral Antibiotics on Health-related Quality of life after Mandibular Third Molar Surgery: An Observational Study
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DOI：
10.4103/1119-3077.183235
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发表时间：
2017-09-01
影响因子：
0.9
通讯作者：
Aregbesola, S. B.
中科院分区：
文献类型：
--
作者：
Braimah, R. O.;Ndukwe, K. C.;Aregbesola, S. B.
目的：比较抗生素对第三磨牙手术后健康相关生活质量（QoL）的影响。材料与方法：研究对象为135例在局部麻醉下需要行下颌第三磨牙拔除手术且符合纳入标准的受试者。受试者被随机分为3组，每组45人：a组延长阿莫西林/克拉维酸（英国葛兰素史克公司），术前1克，然后625 mg BD，持续5天；b组预防性阿莫西林/克拉维酸（英国葛兰素史克公司）术前仅1克；c组预防性左氧氟沙星术前仅1克。在术前和术后第1、3、5、7和14天使用英国口腔健康相关生活质量（OHRQoL）问卷对患者进行评估。结果：本研究表明，手术切除阻生牙对患者的生活质量产生了负面影响，包括身体、社会和心理方面的生活。三组比较，A组生活质量评分略高；虽然，他们之间没有统计学上的显著差异。研究表明，第三磨牙手术后给予抗生素后临床恢复较好。结论：第三磨牙术后第1、3天OHRQoL明显恶化。A组患者的生活质量也略好于B、C组，但差异无统计学意义。
Aim: To compare the impact of antibiotics on health-related quality of life (QoL) outcomes following third molar surgery. Materials and Methods: The study population consisted of 135 subjects that required surgical extraction of mandibular third molar under local anesthesia and met the inclusion criteria. The subjects were randomized into three study groups of 45 subjects each: Group A-extended amoxicillin/clavulanic acid (GlaxoSmithKline Beecham England), 1 gram pre-operatively and then 625 mg BD for 5 days Group B-prophylactic amoxicillin/clavulanic acid (GlaxoSmithKline Beecham England) 1 gram pre-operatively only, and Group C-prophylactic levofloxacin 1 gram pre-operatively only. Patients were assessed pre- and post-operatively on days 1, 3, 5, 7, and 14 using the United Kingdom oral health-related QoL (OHRQoL) questionnaire. Results: This study showed that surgical removal of impacted teeth exerted a negative influence on patient's QoL across various physical, social, and psychological aspects of life. Comparing the three groups, Group A showed a slightly better QoL score; although, there was no statistically significant difference among them. Studies have shown better clinical recovery following administration of antibiotics after third molar surgery. Conclusion: There was a significant deterioration in OHRQoL in the immediate postoperative period, particularly postoperative days 1 and 3 following third molar surgery. QoL was also observed to be slightly better in Group A than Groups B and C, although this was not statistically significant.