Enhanced energy expenditure and fat oxidation in humans with. high BMI scores by the ingestion of novel and non-pungent capsaicin analogues (capsinoids)
Enhanced energy expenditure and fat oxidation in humans with. high BMI scores by the ingestion of novel and non-pungent capsaicin analogues (capsinoids)
复制标题
DOI：
10.1271/bbb.60341
复制
发表时间：
2007-02-01
影响因子：
1.6
通讯作者：
Takahashi, Michio
中科院分区：
文献类型：
--
作者：
Inoue, Naohiko;Matsunaga, Yoshiko;Takahashi, Michio
对44例受试者服用辣椒素（低辛辣辣椒素类似物）4周后的生理生化指标进行监测。受试者被随机分为3组：CSNs3组（3 mg/kg辣椒素）、CSNs10组（10 mg/kg辣椒素）和对照组（安慰剂）。测量是在早上对夜间禁食的受试者进行的。与给药前相比，耗氧量（VO2）、静息能量消耗（REE）和脂肪氧化略有增加，但增幅不显著。脂肪氧化的增加与身体质量指数（BMI）呈正相关。因此，对BMI为>= 25的受试者进行了荟萃分析（n = 28）。因此，CSNs10组不仅VO2显著升高（p < 0.05），而且CSNs10组的REE和CSNs3、CSNs10组的脂肪氧化有升高的趋势（p < 0.1）。因此，摄入辣椒素能够提高人类的能量消耗和脂肪燃烧，尤其是那些高BMI的人。
The biochemical and physiological indices were monitored in 44 subjects after 4-week capsinoids (capsaicin analogues with low pungency) intake. The subjects were randomly assigned to 3 groups: CSNs3 (3 mg/kg of capsinoids), CSNs10 (10 mg/kg of capsinoids) and the control (placebo). Measurements were performed in the morning on overnight-fasted subjects. The oxygen consumption (VO2), resting energy expenditure (REE) and fat oxidation increased slightly compared to pre-administration values without any adverse effects, although the increase was not significant. The increase in fat oxidation was positively and significantly correlated with the body mass index (BMI). A meta-analysis was therefore conducted on a subgroup consisting of subjects with BMI >= 25 (n = 28). As a result, not only VO2 increased significantly (p < 0.05) in the CSNs10 group, but also REE in the CSNs10 group and fat oxidation in the CSNs3 and CSNs10 groups tended to increase (p < 0.1). Consequently, a capsinoids intake would be able to enhance the energy expenditure and fat burning in humans, particularly those with high BMI.