Glutaraldehyde and glyoxal cross-linked chitosan microspheres for controlled delivery of centchroman
Glutaraldehyde and glyoxal cross-linked chitosan microspheres for controlled delivery of centchroman
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DOI：
10.1016/j.carres.2006.02.003
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发表时间：
2006-05-01
影响因子：
3.1
通讯作者：
Jabrail, FH
中科院分区：
文献类型：
--
作者：
Gupta, KC;Jabrail, FH
以不同分子量（MWs）和不同脱乙酰度（DDAs）的壳聚糖为原料，制备戊二醛和乙二醛交联微球，在生理条件下缓释中心色素。采用不同方法测定壳聚糖中的DDA，将样品分为低（48%）、中（62%）和高（75%）DDA的壳聚糖。用扫描电镜（SEM）测定了微球的大小和形状，并通过戊二醛或乙二醛交联的微球吸附孟加拉玫瑰染料测定了微球的疏水性。研究了微球中分子量、DDA和交联度对溶胀度的影响，并通过对中心色曼的加载和释放进行了研究。乙二醛交联微球与壳聚糖微球和戊二醛交联微球配合使用，结构紧凑，疏水，缓释效果好。浓度浓度随时间的平方根呈线性分数释放，表明浓度浓度具有菲克行为，微球也表现出零级释放动力学。(c) 2006 Elsevier Ltd.版权所有。
Glutaraldehyde and glyoxal cross-linked microspheres were prepared using chitosan with different molecular weights (MWs) and degrees of deacetylation (DDAs) for sustained release of centchroman under physiological conditions. The DDA in chitosan was determined by different methods, and the samples were categorized as chitosan with low (48%), medium (62%), and high (75%) DDA. The size and shape of the microspheres were determined by scanning electron microscopy (SEM), and hydrophobicity was determined by adsorption of Rose Bengal dye on microspheres cross-linked with glutaraldehyde or glyoxal. The effect of MW, DDA, and degree of cross-linking in microspheres was studied on the degree of swelling, as well as by the loading and release of centchroman. The glyoxal cross-linked microspheres were more compact and hydrophobic and showed better sustained release in companion to chitosan microspheres and glutaraldehyde cross-linked microspheres. The linear fractional release of centchroman with the square root of time indicated a Fickian behavior of centchroman, and the microspheres also showed zero-order release kinetics for centchroman. (c) 2006 Elsevier Ltd. All rights reserved.