Genetic and environmental influences on migraine: A twin study across six countries
Genetic and environmental influences on migraine: A twin study across six countries
复制标题
DOI：
10.1375/twin.6.5.422
复制
发表时间：
2003-10-01
期刊：
影响因子：
--
通讯作者：
Palotie, A
中科院分区：
文献类型：
--
作者：
Mulder, EJ;van Baal, C;Palotie, A
偏头痛是一种常见的神经血管性脑疾病，表现为反复发作的致残性头痛。本研究的目的是比较6个参与genome eutwin项目的国家偏头痛的患病率和遗传性，其中包括29,717对双胞胎。偏头痛的评估是通过问卷进行的，而问卷在大多数国家之间存在差异。在丹麦和荷兰女性中患病率最高（分别为32%和34%），而在年轻和年长的芬兰人群中患病率最低（分别为13%和10%）。估计的遗传变异（遗传力）在所有国家的性别之间都是显著的和相同的。遗传率从34%到57%不等，澳大利亚的估计值最低，芬兰、荷兰和丹麦的老年人群估计值最高。有一些迹象表明，部分遗传变异是非加性的，但这只在瑞典很重要。除了遗传因素外，双胞胎成员之间不共享的环境影响也会导致偏头痛。在参与国对偏头痛的定义统一之后，GenomEUtwin项目将为识别偏头痛相关基因提供强大的资源。
Migraine is a common neurovascular brain disorder that is manifested in recurrent episodes of disabling headache. The aim of the present study was to compare the prevalence and heritability of migraine across six of the countries that participate in GenomEutwin project including a total number of 29,717 twin pairs. Migraine was assessed by questionnaires that differed between most countries. It was most prevalent in Danish and Dutch females (32% and 34%, respectively), whereas the lowest prevalence was found in the younger and older Finnish cohorts (13% and 10%, respectively). The estimated genetic variance (heritability) was significant and the same between sexes in all countries. Heritability ranged from 34% to 57%, with lowest estimates in Australia, and highest estimates in the older cohort of Finland, the Netherlands, and Denmark. There was some indication that part of the genetic variance was non-additive, but this was significant in Sweden only. In addition to genetic factors, environmental effects that are non-shared between members of a twin pair contributed to the liability of migraine. After migraine definitions are homogenized among the participating countries, the GenomEUtwin project will provide a powerful resource to identify the genes involved in migraine.