THE EFFECTS OF POSTERIOR SUBTENON INJECTION OF TRIAMCINOLONE ACETONIDE IN PATIENTS WITH INTERMEDIATE UVEITIS
THE EFFECTS OF POSTERIOR SUBTENON INJECTION OF TRIAMCINOLONE ACETONIDE IN PATIENTS WITH INTERMEDIATE UVEITIS
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DOI：
10.1016/s0002-9394(14)73759-6
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发表时间：
1995-07-01
影响因子：
4.2
通讯作者：
HOLLAND, GN
中科院分区：
文献类型：
--
作者：
HELM, CJ;HOLLAND, GN
目的：眼周注射皮质类固醇是治疗中度葡萄膜炎患者视力下降的常用治疗方法。然而，这种治疗有可能产生严重的副作用。我们试图确定这种注射对一系列患者的影响。方法：我们回顾了连续20例（20只眼，43次注射）接受曲安奈德后腱下注射治疗中度葡萄膜炎的患者的病历。我们收集了视觉结果和副作用的数据。结果：中位随访时间为23.5个月（1 ~ 50个月）。初次注射后检查的18例患者中有12例（67%）Snellen视力至少改善了两条线。改善的中位时间为三周。视力改善患者的中位年龄为29.0岁，而无反应患者的中位年龄为41.5岁（P = 0.024）。校正后患者年龄对治疗的反应与不吸烟史之间存在弱相关性（P = 0.073）。6例患者（30%）出现眼压升高（> 21 mm Hg），发病时间中位数为首次注射后3周；至峰值升高的中位数间隔（中位数，32 mm Hg；范围，25 ~ 40 mm Hg）为注射后14周。结论：静脉注射曲安奈德是治疗中度葡萄膜炎相关视力下降的有效方法，但可能导致部分患者眼压升高。
PURPOSE: Periocular injection of corticosteroids is a common treatment for vision loss in patients with intermediate uveitis. However, this treatment has the potential for serious side effects. We sought to determine the effects of such injections in a series of patients.METHODS: We reviewed charts of 20 consecutive patients (20 eyes, 43 injections) who had received posterior subtenon injections of triamcinolone acetonide for treatment of intermediate uveitis. We collected data on visual outcome and side effects.RESULTS: Median follow-up was 23.5 months (range, one to 50 months). Snellen visual acuity improved by at least two lines in 12 (67%) of 18 patients who were examined after initial injection. Median time to improvement was three weeks. Patients with visual improvement had a median age of 29.0 years, compared with 41.5 years for nonresponders (P = .024), There was a weak association between response to treatment and a history of not smoking (P = .073) after correction for patient age. Increase of intraocular pressure (> 21 mm Hg) occurred in six patients (30%), with onset at a median of three weeks after initial injection; the median interval to peak increase (median, 32 mm Hg; range, 25 to 40 mm Hg) was 14 weeks after the injection.CONCLUSIONS: A subtenon injection of triamcinolone acetonide appears to be an effective treatment for decreased vision associated with intermediate uveitis but may contribute to increase of intraocular pressure in some patients with this disorder.