Ecto-mesenchymal stem cells: a new player for immune regulation and cell therapy.
Ecto-mesenchymal stem cells: a new player for immune regulation and cell therapy.
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外间充质干细胞：免疫调节和细胞治疗的新参与者。
DOI：
10.1038/cmi.2017.69
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发表时间：
2017
影响因子：
24.1
通讯作者：
Liwei Lu
中科院分区：
文献类型：
--
作者：
Ke Rui;Xiang Lin;Jie Tian;Xiaohui Wang;Lingyun Sun;Xiaoping Hong;Dongzhou Liu;Shengjun Wang;Liwei Lu
大量研究表明，间充质干细胞（mesenchymal stem cells，MSCs）是一种多能的中胚层来源的基质细胞，可以分化为脂肪细胞、成骨细胞、软骨细胞、肌细胞和神经细胞等多种细胞类型。1 MSC存在于许多器官和组织中，包括骨髓、心脏、肺、肌肉、外周血、脂肪组织、软骨、滑膜、牙髓、扁桃体、脐带、胎盘、胸腺和嗅觉粘膜。1.骨髓间充质干细胞具有强大的免疫抑制功能和组织修复能力，这促进了骨髓间充质干细胞在治疗各种涉及血管生成和纤维化的疾病，包括风湿性疾病和移植物抗宿主病中的临床应用。2，3在这里，我们提供了一个简短的评论新出现的证据的免疫调节功能和潜在的应用外间充质干细胞。
Extensive studies have demonstrated that mesenchymal stem cells (MSCs) are multipotent mesoderm-derived stromal cells that can differentiate into a variety of cell types, including adipocytes, osteoblasts, chondrocytes, myocytes and neuronal cells. 1 MSCs are found in numerous organs and tissues, including bone marrow, heart, lung, muscle, peripheral blood, adipose tissue, cartilage, synovium, dental pulp, tonsil, umbilical cord, placenta, thymus and olfactory mucosa. 1 MSCs have been shown to possess potent immunosuppressive functions and tissue repair capacities, which have facilitated the clinical applications of MSCs in treating a diverse range of disorders involving angiogenesis and fibrosis, including rheumatic diseases and graft-versus-host diseases. 2, 3 Here, we provide a brief commentary on newly emerging evidence of the immunoregulatory function and potential application of ecto-mesenchymal stem cells.