Are meningeal hemangiopericytoma and mesenchymal chondrosarcoma the same?: a study of HEY1-NCOA2 fusion.
Are meningeal hemangiopericytoma and mesenchymal chondrosarcoma the same?: a study of HEY1-NCOA2 fusion.
复制标题
脑膜血管外皮细胞瘤和间充质软骨肉瘤相同吗？：HEY1-NCOA2 融合的研究。
DOI：
10.1309/ajcpgungp52zsdns
复制
发表时间：
2013
影响因子：
3.5
通讯作者：
B. Rubin
中科院分区：
文献类型：
--
作者：
K. Fritchie;Long Jin;A. Ruano;Andre M Oliveira;B. Rubin
目标
OBJECTIVES
Meningeal hemangiopericytoma (HPC) and mesenchymal chondrosarcoma are aggressive neoplasms with a propensity to involve the meninges and dura. In addition to similar clinical presentations, both meningeal HPC and mesenchymal chondrosarcoma share overlapping morphologic features, including ovoid cells, variable collagen deposition, and a branching vascular pattern. Recently, a novel HEY1-NCOA2 fusion was reported as a recurrent event in mesenchymal chondrosarcomas.
METHODS
Thirteen mesenchymal chondrosarcomas and 18 meningeal HPCs were identified from surgical pathology archives, and the tumors were evaluated for HEY1-NCOA2 fusion with reverse transcriptase-polymerase chain reaction (RT-PCR).
RESULTS
HEY1-NCOA2 fusion transcript was detected in all six cases of mesenchymal chondrosarcoma but in none of the meningeal HPC cases (0/11) that were evaluable with RT-PCR.
CONCLUSIONS
These results show that (1) meningeal HPC and mesenchymal chondrosarcoma are distinct at the molecular level, and (2) the identification of HEY1-NCOA2 can be used as an auxiliary diagnostic tool to differentiate these entities.
影响因子：
12.7
作者：
Louis DN;Ohgaki H;Wiestler OD;Cavenee WK;Burger PC;Jouvet A;Scheithauer BW;Kleihues P
通讯作者：
Kleihues P