Elastic scattering spectroscopy as an optical marker of inflammatory bowel disease activity and subtypes.
Elastic scattering spectroscopy as an optical marker of inflammatory bowel disease activity and subtypes.
复制标题
弹性散射光谱作为炎症性肠病活动和亚型的光学标记。
DOI：
10.1097/mib.0000000000000058
复制
发表时间：
2014
影响因子：
4.9
通讯作者：
Singh,SatishK
中科院分区：
文献类型：
--
作者：
Rodriguez-Diaz,Eladio;Atkinson,Christopher;Jepeal,LisaI;Berg,Adam;Huang,ChristopherS;Cerda,SandraR;OʼBrien,MichaelJ;Bigio,IrvingJ;Farraye,FrancisA;Singh,SatishK
BackgroundIn 10% to 15% of individuals, inflammatory bowel disease (IBD) is difficult to classify as ulcerative colitis (UC) or Crohn's disease (CD). Previous work has demonstrated that probe-based elastic scattering spectroscopy (ESS) can produce spectra, informed by parameters like tissue ultrastructure and hemoglobin content, capable of differentiating pathologies. This study investigates whether ESS is an in vivo optical biomarker for the presence, activity, and type of IBD in the colon.MethodsPilot study, a retrospective data analysis. ESS spectra of endoscopically normal and inflamed colon were obtained from 48 patients with IBD and 46 non-IBD controls. Measurements from patients with IBD were categorized as CD or UC based on clinical diagnosis. Spectra were analyzed using high-dimensional methods. Leave-one-patient-out cross-validation was used to obtain diagnostic performance estimates.ResultsPatients with IBD were distinguishable from non-IBD controls with a sensitivity of 0.93 and specificity of 0.91 based on readings from endoscopically normal mucosa, and 0.94 and 0.93 from inflamed mucosa. In patients with IBD, histologically normal and inflamed colon were distinguishable with per-class accuracies of 0.83 and 0.89, respectively; histologically normal from inactive inflammation with accuracies of 0.73 and 0.89, respectively; and inactive from active colitis with accuracies of 0.87 and 0.84, respectively. The diagnosis of CD versus UC was made with per-class accuracies of 0.92 and 0.87 in normal and 0.87 and 0.85 in inflamed mucosa, respectively.ConclusionsESS, a simple, low-cost clinically friendly optical biopsy modality, has the potential to enhance the endoscopic assessment of IBD and its activity in real time and may help to distinguish CD from UC.
