HIGH-FREQUENCY MEIOTIC GENE CONVERSION BETWEEN REPEATED GENES ON NONHOMOLOGOUS CHROMOSOMES IN YEAST
HIGH-FREQUENCY MEIOTIC GENE CONVERSION BETWEEN REPEATED GENES ON NONHOMOLOGOUS CHROMOSOMES IN YEAST
复制标题
DOI：
10.1073/pnas.82.10.3350
复制
发表时间：
1985-01-01
影响因子：
11.1
通讯作者：
PETES, TD
中科院分区：
文献类型：
--
作者：
JINKSROBERTSON, S;PETES, TD
一个遗传系统，允许检测减数分裂重组事件之间的非同源染色体上的重复序列被用于酵母s。啤酒。这些序列之间的突变发生的频率约为0.5%，观察到的事件是不可逆的（基因转换）。令人惊讶的是，在这项研究中观察到的非同源染色体上的重复基因之间的转换频率与等位基因之间的转换频率相似。结合联会复合体在减数分裂重组中的作用以及相互和非相互重组之间的关系，讨论了这一结果。
A genetic system that allows detection of meiotic recombination events between repeated sequences on nonhomologous chromosomes was used in the yeast s. cerevisiae. Recombination between these sequences occurs at a frequency of about 0.5%, and the events observed were nonreciprocal (gene conversions). Surprisingly, the frequency of conversion between the repeated genes on nonhomologous chromosomes observed in this study is similar to that observed between allelic genes. This result is discussed in connection with the role of the synaptonemal complex in meiotic recombination and with the relationship between reciprocal and nonreciprocal recombination.