Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release.
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release.
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DOI：
10.1021/acs.chemrev.5b00346
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发表时间：
2016-02-24
期刊：
影响因子：
62.1
通讯作者：
Farokhzad OC
中科院分区：
文献类型：
--
作者：
Kamaly N;Yameen B;Wu J;Farokhzad OC
生物可降解聚合物的发展代表了50多年来的医学革命，并导致药物输送，生物材料，组织工程和医疗器械开发方面的重大生物技术进步，同时以独特的合作方式将化学家，工程师，生物学家和医生聚集在一起。这场革命的时间框架反映了以肽、蛋白质、核酸和其他生物活性分子形式出现的更有效的治疗方法的发现。许多这些现代治疗剂的短半衰期，以及先前鉴定的小分子药物的非特异性分布和毒性，已经成为聚合物药物递送平台开发的主要驱动力。早期的宏观和微观药物递送系统的成功临床转化导致了控释纳米药物递送平台的发展，其能够克服药理学限制，具有比常规剂型更大的优势。用于研究药物控释机制的合成方法、制造方法和数学模型的研究和发现已经导致能够产生能够局部和持续递送的可调聚合物纳米颗粒（NP）药物递送系统，从而促进药物治疗指数的改善。聚合物药物递送平台的控制治疗药物释放的能力和极其通用的性质提供了许多重要的优点（图1）。从20世纪60年代开始，聚合物药物递送在该领域的著名研究人员的开创性工作中蓬勃发展，包括Folkman，Langer，Higuchi，Roseman，Peppas，Heller，Ringsdorf和Speiser。1 - 18我们见证了药物递送能力的演变，从最初在宏观药物仓库、植入物和缝合材料中使用控释聚合物，到可注射的微米级受控药物递送系统，如微粒，再到纳米级药物递送，这可能在未来几十年内逐渐成为制药公司管道的更大部分。19，20迄今为止，我们已经看到了用于小分子药物的靶向和可调控释聚合物NP的第一个实验室到床边的转化，从最初的体外概念验证，21，22到成功的体内研究，23，24为人体测试和正在进行的多种癌症类型的II期临床试验奠定了基础。25可控释放聚合物纳米粒的出现促进了对合成方法、生物缀合技术的新研究，以及科学出版物的快速增长，这些出版物涉及使用靶位点激活的化学反应，这些反应引发纳米粒结构、形状、化学和降解速率的变化。调节聚合物NP的物理化学性质和调节聚合物NP的物理化学性质的能力是有利的。
The development of biodegradable polymers represents a revolution in medicine spanning over 50 years and leading to significant biotechnological advancements in drug delivery, biomaterials, tissue engineering, and medical device development while bringing together chemists, engineers, biologists, and physicians in a unique and collaborative manner. The time frame of this revolution mirrors discoveries of more potent therapeutics in the form of peptides, proteins, nucleic acids, and other bioactive molecules. The short half-lives of many of these modern therapeutics, in addition to the nonspecific distribution and toxicity of previously identified small molecule drugs, has been a major driving force for the development of polymeric drug delivery platforms. The successful clinical translation of the earlier macro-and micro-drug-delivery systems has led to the evolution of controlled-release nanodrug delivery platforms that are capable of overcoming pharmacological limitations with substantial advantages over conventional dosage forms. Investigations and discoveries in synthetic methodologies, fabrication methods, and mathematical models for studying the mechanisms of controlled drug release have led to the ability to create tunable polymeric nanoparticle (NP) drug delivery systems capable of localized and sustained delivery, facilitating improvements in the therapeutic index of drugs. The ability to control the release of therapeutics and the extremely versatile nature of polymeric drug delivery platforms offer numerous important advantages (Figure 1).Starting for the most part in the 1960s, polymeric drug delivery has flourished since the pioneering works of notable researchers in the field, including Folkman, Langer, Higuchi, Roseman, Peppas, Heller, Ringsdorf, and Speiser. 1− 18 We have witnessed an evolution in drug delivery capabilities from the initial use of controlled-release polymers in macroscopic drug depots, implants, and suture materials to injectable microscale controlled drug delivery systems, such as microparticles, to nanoscale drug delivery, which may progressively represent a bigger part of the pipeline of pharmaceutical companies over the next few decades. 19, 20 To date we have seen the first bench-to-bedside translation of targeted and tunable controlled release polymeric NPs for small molecule drugs, from initial proof-of-concept in vitro, 21, 22 to successful in vivo investigations, 23, 24 which have laid the foundation for human testing and ongoing phase II clinical trials for multiple cancer types. 25 The emergence of controlledrelease polymeric NPs has fostered novel investigations of synthetic methodologies, bioconjugation techniques, and a rapid proliferation of scientific publications addressing the use of target-site activated chemical reactions that trigger changes in NP structure, shape, chemistry, and degradation rates. The ability to tune the physicochemical properties of polymeric NPs and to
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DOI：
10.1073/pnas.97.2.745
发表时间：
2000-01-18
影响因子：
11.1
作者：
Arunachalam, B;Phan, UT;Cresswell, P
通讯作者：
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影响因子：
5.6
作者：
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影响因子：
3.2
作者：
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影响因子：
7.015
作者：
Aguirre-Chagala, Yanet Elised;Santos, Jose Luis;Herrera-Alonso, Margarita
通讯作者：
Herrera-Alonso, Margarita
影响因子：
16.6
作者：
Bagalkot, Vaishali;Farokhzad, Omid C.;Jon, Sangyong
通讯作者：
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