Stepwise synaptic plasticity events drive the early phase of memory consolidation
Stepwise synaptic plasticity events drive the early phase of memory consolidation
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DOI：
10.1126/science.abj9195
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发表时间：
2021-11-12
期刊：
影响因子：
56.9
通讯作者：
Hayashi, Yasunori
中科院分区：
文献类型：
--
作者：
Goto, Akihiro;Bota, Ayaka;Hayashi, Yasunori
记忆最初是在海马体中编码的，但随后会巩固到大脑皮层。虽然突触可塑性是这些过程的关键，但其精确的时空分布仍然知之甚少。利用光遗传学技术选择性地消除长时程增强（LTP），我们发现突触可塑性的不同阶段起着不同的作用。第一波在海马体局部起作用，赋予情境特异性。在同一天的睡眠中，第二波将这些神经元组织成同步放电的集合。最后，在第二天睡眠时，前扣带皮层的LTP是进一步稳定记忆所必需的。这证明了在记忆巩固的早期阶段，可塑性事件的精确定位、时间和特征贡献。
Memories are initially encoded in the hippocampus but subsequently consolidated to the cortex. Although synaptic plasticity is key to these processes, its precise spatiotemporal profile remains poorly understood. Using optogenetics to selectively erase long-term potentiation (LTP) within a defined temporal window, we found that distinct phases of synaptic plasticity play differential roles. The first wave acts locally in the hippocampus to confer context specificity. The second wave, during sleep on the same day, organizes these neurons into synchronously firing assemblies. Finally, LTP in the anterior cingulate cortex during sleep on the second day is required for further stabilization of the memory. This demonstrates the precise localization, timing, and characteristic contributions of the plasticity events that underlie the early phase of memory consolidation.