Review: diagnosis of chemotherapy lung.
Review: diagnosis of chemotherapy lung.
复制标题
回顾：化疗肺的诊断。
DOI：
10.2214/ajr.136.1.33
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
G. Gamsu
中科院分区：
文献类型：
--
作者：
H. Sostman;C. Putman;G. Gamsu
在接受化疗的患者中观察到的弥漫性肺部疾病具有多种病因，包括感染、与基础疾病的牵连、辐射或诊断剂的损伤以及化疗药物的毒性。除了伴随使用的治疗剂，先前给予的细胞毒性药物可能会增强放疗的毒性，反之亦然。放射科医生与临床医生一起，通过将放射学和临床数据相关联，可以评估药物引起的肺部疾病的概率。有用的临床数据包括与肺部相关的体征和症状、肺功能检查结果、给药剂量和时间表以及有关合并或既往药物或放射治疗的信息。有用的影像学资料包括胸片上的密度分布，有无胸淋巴结病，有无胸腔积液。诊断是困难的，因此临床和亚临床药物性肺炎的发病率是不准确的。
Diffuse pulmonary diseases seen in patients receiving chemotherapy have a wide variety of etiologies including infection, involvement with the underlying disease, injury from radiation or diagnostic agents, and toxicity from chemotherapeutic drugs. In addition to concomitantly used therapeutic agents, previously administered cytotoxic drugs may enhance the toxicity of radiotherapy and vice versa. Together with the clinician, the radiologist may be able to assess the probability of drug-induced lung disease by correlating radiographic and clinical data. Useful clinical data include signs and symptoms related to the lungs, pulmonary function test results, dose and schedule of drug administration, and information concerning concomitant or previous drug or radiation therapy. Useful radiographic data include the distribution of densities seen on the chest radiograph, the presence or absence of thoracic adenopathy, and the presence or absence of pleural effusion. The diagnosis is difficult, and thus the incidence of clinical and subclinical drug-induced pneumonitis is not accurately known.