Effects of high fat diet and perinatal dioxin exposure on development of body size and expression of platelet-derived growth factor receptor β in the rat brain
Effects of high fat diet and perinatal dioxin exposure on development of body size and expression of platelet-derived growth factor receptor β in the rat brain
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DOI：
10.3233/jin-170025
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发表时间：
2017-01-01
影响因子：
1.8
通讯作者：
Nishijo, Hisao
中科院分区：
文献类型：
--
作者：
Bor, Amartuvshin;Nishijo, Muneko;Nishijo, Hisao
Environmental exposure to dioxins, consumption of a high fat diet, and platelet-derived growth factor receptor beta signaling in the brain affect feeding behavior, which is an important determinant of body growth. In the present study, we investigated the effects of prenatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and high fact diet after weaning on body growth and expression of platelet-derived growth factor receptor beta in the brain in rat pups. Subjects from the control and dioxin exposure groups were assigned to 1 of 3 different diet groups: standard diet, high fat diet in the juvenile period, or high fat diet in adulthood. Body weight gain rate in the juvenile high fat diet group and the length gain rate in the adult high fat diet group were greater than the corresponding values in the standard diet group only in male offspring, although the effects of dioxin exposure on growth were not significant. Consumption of a high fat diet decreased platelet-derived growth factor receptor beta levels in the amygdala and hippocampus in both sexes compared to control groups, while 2,3,7,8-tetrachlorodibenzo-p-dioxin decreased platelet-derived growth factor receptor platelet-derived growth factor receptor beta levels in the amygdala and striatum only in females receiving an high fat diet. Furthermore, platelet-derived growth factor receptor beta levels in the hippocampus and platelet-derived growth factor receptor beta striatum were inversely correlated with increases in body length, while changes in platelet-derived growth factor receptor beta in the amygdala and nucleus accumbens were significantly correlated to body weight gain or body mass index. In conclusion, these findings suggest that these 2,3,7,8-tetrachlorodibenzo-p-dioxin and high fat diet-induced changes in body growth and feeding behaviors might be partially mediated by changes in brain platelet-derived growth factor receptor beta levels.
