A new modification of anti-tubercular active molecules
A new modification of anti-tubercular active molecules
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DOI：
10.1016/j.bmc.2007.01.051
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发表时间：
2007-04-01
影响因子：
3.5
通讯作者：
Kaustova, Jarmila
中科院分区：
文献类型：
--
作者：
Imramovsky, Ales;Polanc, Slovenko;Kaustova, Jarmila
The connection of two active molecules across an easily released bridge as a new type of potentially active molecule has been studied. The synthesis is based on derivatives that originate from isonicotinoyl hydrazide, pyrazinamide, p-ammosalicylic acid (PAS), ethambutol, and ciprofloxacin. The lipophilicity, hydrolysis (stability of the compounds), and antituberculotic activity as well as the structure-lipophilicity and structure-activity relationships are discussed. (c) 2007 Elsevier Ltd. All rights reserved.
