Toluene-induced hearing loss: A mid-frequency location of the cochlear lesions
Toluene-induced hearing loss: A mid-frequency location of the cochlear lesions
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DOI：
10.1016/s0892-0362(96)00214-0
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发表时间：
1997-03-01
影响因子：
2.9
通讯作者：
Placidi, V
中科院分区：
文献类型：
--
作者：
Campo, P;Lataye, R;Placidi, V
吸入甲苯（1000 - 2000ppm， 6小时/天，5天/周，4周）是一种耳毒性溶剂，严重损害成年龙-埃文斯大鼠的耳蜗。通过记录下丘近场电位来检测听觉功能。令人惊讶的是，电生理结果并不能反映组织学观察到的所有耳蜗损伤。所有甲苯处理大鼠耳蜗中、中尖转时耳蜗外毛细胞均有丢失，而耳蜗基底转则保存较好。第三行外毛细胞比第二行损伤更严重，第二行本身比第一行损伤更严重。在本研究中报告了有关甲苯剂量的耳蜗损伤的位置。(C) 1997爱思唯尔科学有限公司
Inhaled toluene (from 1000 to 2000 ppm, 6 h/day, 5 days/week, 4 weeks) is an ototoxic solvent that severely damaged the cochlea in adult Long-Evans rats. Auditory function was tested by recording near field potentials from the inferior colliculus. Surprisingly, the electrophysiologic results did not reflect all the cochlear damage observed by histology. Loss of outer hair cells of the organ of Corti occurred in all toluene-treated rats in middle and mid-apical turns, whereas the basal turn of the cochlea was fairly well preserved. The third row of outer hair cells was more injured than the second row, which itself was more injured than the first row. The locations of the cochlear lesions are reported in the present study with regard to the toluene dose. (C) 1997 Elsevier Science Inc.