The matrix in focus: new directions in extracellular matrix research from the 2021 ASMB hybrid meeting.
The matrix in focus: new directions in extracellular matrix research from the 2021 ASMB hybrid meeting.
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DOI：
10.1242/bio.059156
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发表时间：
2022-01-15
期刊：
影响因子：
2.4
通讯作者：
Naba A
中科院分区：
文献类型：
--
作者：
Nerger BA;Jones TM;Rose KWJ;Barqué A;Weinbaum JS;Petrie RJ;Chang J;Vanhoutte D;LaDuca K;Hubmacher D;Naba A
细胞外基质（extracellular matrix， ECM）是一种复杂的大分子组合，为细胞提供结构支持和分子信号，并调节细胞的行为。ECM最初被认为是一种被动的机械结构，几十年的研究已经证明了ECM如何动态调节发育、体内平衡和疾病进展中的多种细胞过程。2021年9月，美国基质生物学学会（ASMB）组织了一次混合科学会议，整合了面对面和虚拟形式，讨论了ECM研究的最新进展。在这里，我们强调了会议中出现的令人兴奋的科学进展，包括(1)使用模型系统进行基础和翻译ECM研究，(2)ECM靶向方法作为治疗方式，(3)细胞-ECM相互作用，以及(4)ECM作为组织工程策略的关键组成部分。此外，我们还讨论了ASMB如何将指导、职业发展、多样性、公平和包容性倡议纳入虚拟和面对面的活动中。最后，我们反思了混合科学会议的形式，以及它将如何帮助ASMB完成其使命。摘要：我们描述了由美国基质生物学学会组织的2021年混合科学会议上提出的细胞外基质研究的最新进展和新方向。
The extracellular matrix (ECM) is a complex assembly of macromolecules that provides both architectural support and molecular signals to cells and modulate their behaviors. Originally considered a passive mechanical structure, decades of research have since demonstrated how the ECM dynamically regulates a diverse set of cellular processes in development, homeostasis, and disease progression. In September 2021, the American Society for Matrix Biology (ASMB) organized a hybrid scientific meeting, integrating in-person and virtual formats, to discuss the latest developments in ECM research. Here, we highlight exciting scientific advances that emerged from the meeting including (1) the use of model systems for fundamental and translation ECM research, (2) ECM-targeting approaches as therapeutic modalities, (3) cell-ECM interactions, and (4) the ECM as a critical component of tissue engineering strategies. In addition, we discuss how the ASMB incorporated mentoring, career development, and diversity, equity, and inclusion initiatives in both virtual and in-person events. Finally, we reflect on the hybrid scientific conference format and how it will help the ASMB accomplish its mission moving forward. Summary: We describe recent advances and new directions in extracellular matrix research presented at the 2021 hybrid scientific meeting organized by the American Society for Matrix Biology.