TPJ-M1 interaction in the control of shared representations: New insights from tDCS and TMS combined
TPJ-M1 interaction in the control of shared representations: New insights from tDCS and TMS combined
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DOI：
10.1016/j.neuroimage.2016.10.050
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发表时间：
2017-02-01
期刊：
影响因子：
5.7
通讯作者：
Brass, Marcel
中科院分区：
文献类型：
--
作者：
Bardi, Lara;Gheza, Davide;Brass, Marcel
有大量的证据表明，感知和内部计划的行动有一个共同的表征基础：行动观察可以诱导一种自动模仿他人的倾向。然而，如果感知和执行的行为是基于共享表征的，那么问题就出现了，我们如何区分自我相关表征和他人相关表征。有人认为，共享表征的控制涉及以颞顶交界处（TPJ）为中心的神经网络。然而，TPJ在控制共享表示方面的具体作用仍然不清楚。在冲突情境中，参与者必须执行行动A，同时观察行动B，TPJ可能会促进相关的行动A或抑制不相关的行动B（镜像反应）。在本研究中，我们使用经颅直流电刺激（tDCS）的条件下，在右颞顶叶交界处（TPJ）的神经活动。然后，我们分析了皮质脊髓输出的索引由运动诱发电位（MEP）引起的单脉冲TMS（spTMS）的左初级运动皮层（M1）在行动观察的冲突任务的背景下。结果表明，tDCS介导的增加控制不需要衰减的任务无关的反应激活：运动镜像的效果没有抑制或减少。相反，通过阳极tDCS促进TPJ活动选择性地增强了指示的运动计划（自我相关的表示）。这一结果支持了TPJ在检测自我相关表征和他人相关表征之间的不匹配方面起着关键作用的观点，并有助于增强任务相关表征。
There is extensive evidence that perceived and internally planned actions have a common representational basis: action observation can induce an automatic tendency to imitate others. If perceived and executed action, however, are based on shared representations, the question arises how we can distinguish self-related and other-related representations. It has been suggested that the control of shared representations involves a neural network centered on the temporo-parietal junction (TPJ). However, the specific role of the TPJ in controlling shared representations is still not clear. In a conflict situation where participants have to execute action A while observing action B, the TPJ might either facilitate the relevant action A or inhibit the irrelevant action B (mirror response). In the present study, we used transcranial Direct Current Stimulation (tDCS) to condition neural activity in the right temporo-parietal junction (TPJ). We then analyzed the corticospinal output as indexed by motor-evoked potentials (MEPs) induced by single-pulse TMS (spTMS) of the left primary motor cortex (M1) during action observation in the context of a conflict task. Results showed that tDCS-mediated increased control did not entail the attenuation of the task-irrelevant response activation: the effect of motor mirroring was not suppressed or reduced. Rather, facilitating TPJ activity via anodal tDCS selectively enhanced the instructed motor plan (self-related representation). This outcome supports the idea that TPJ plays a critical role in detecting the mismatch between self-related and other-related representations and is at work to enhance task relevant representations.