Bacillus cereus nosocomial infection from reused towels in Japan
Bacillus cereus nosocomial infection from reused towels in Japan
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DOI：
10.1016/j.jhin.2008.04.014
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发表时间：
2008-08-01
影响因子：
6.9
通讯作者：
Yamamoto, T.
中科院分区：
文献类型：
--
作者：
Dohmae, S.;Okubo, T.;Yamamoto, T.
2000年至2005年夏季，蜡样芽孢杆菌医院感染呈上升趋势。2005年，5名患者发生了5例与导管使用有关的血流感染。致病菌株彼此不同，属于新型多位点序列类型（ST）：ST 365、ST 366、ST 367和ST 368。通过脉冲场凝胶电泳进一步区分来自两名患者的两株ST 365菌株。B。在医院布草房中，使用重复使用的（干燥和蒸过的）毛巾（> 10（6）cfu/毛巾）和洗衣机观察到蜡状菌污染。B。毛巾蜡样芽胞杆菌菌株属于ST 167、ST 365、ST 380和ST 382，其中一部分与患者蜡样芽胞杆菌菌株相同或相似。医院里到处都是B病毒。蜡样芽胞杆菌与食物中毒菌株（ST 26、ST 142、ST 381）有明显区别。仅在医院菌株中观察到环丙沙星耐药性。除1株患者分离株外，医院分离株均未检出呕吐毒素和细胞毒素K基因。数据表明，特定的B.蜡样芽胞杆菌菌株在医院内传播，其基因型、抗生素敏感性和毒力基因模式通常与食物中毒不同，在日本，毛巾是重要的污染源，特别是在夏季。(c)2008医院感染协会。由爱思唯尔有限公司出版。保留所有权利。
It was noticed that there was an increase in Bacillus cereus nosocomial infections in the summer from 2000 to 2005. In 2005, five bloodstream infections occurred in five patients related to catheter use. The causative strains were distinct from each other and belonged to novel multilocus sequence types (ST): ST365, ST366, ST367 and ST368. Two ST365 strains from two patients were further distinguished by pulsed-field get electrophoresis. B. cereus contamination was observed with reused (dried and steamed) towels (> 10(6) cfu/towel) and washing machines in hospital linen rooms. B. cereus strains from towels belonged to ST167, ST365, ST380 and ST382, and a proportion of these were the same, or similar, to strains from patients. All the hospital, strains of B. cereus were distinct from those from food-poisoning strains (ST26, ST142, ST381). Ciprofloxacin resistance was observed only in hospital strains. Neither emetic toxin nor cytotoxin K gene, usually present in food poisoning strains, were found in the hospital strains, except for one patient isolate. The data suggest that specific B. cereus strains are circulating within a hospital, with genotypes, antibiotic susceptibilities and virulence gene patterns generally distinct from those of food poisoning, and that in Japan, towels are an important source of contamination, especially in summer. (c) 2008 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.