Behavioral and functional MRI study of attention shift in human verbal working memory
Behavioral and functional MRI study of attention shift in human verbal working memory
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DOI：
10.1016/j.neuroimage.2003.08.043
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发表时间：
2004-01-01
期刊：
影响因子：
5.7
通讯作者：
Hu, XP
中科院分区：
文献类型：
--
作者：
Li, ZH;Sun, XW;Hu, XP
记忆的三重模型提出了在工作记忆中访问不同项目时注意转换的要求[J. Exp.心理学。学着点。记忆认知27（2001）817]。注意力的这种内部焦点仅限于一个项目，并且切换过程是耗时的[Mem. 26（1998）2631]。在当前的研究中，给定一个存储在工作记忆中的三位数列表，我们发现，将注意力转移到“上游”的方向比“下游”的方向需要更长的时间，并且每个转移都是一个“单步”过程。为了研究这种类型的注意转换的神经基础，我们进行了功能性MRI研究。结果显示，至少有三个重要的大脑区域参与，包括左背外侧前额叶皮层，扣带回和内侧枕叶皮层。与没有（或减少）注意力转移要求的控制条件相比，这些区域在注意力转移条件下显示出更大的激活。此外，这些区域的血流动力学活动高度相关，表明它们之间有很强的功能联系。结合最近几项研究的证据，我们的研究结果表明，这些区域在协同支持工作记忆中的注意力转移功能方面发挥着重要而具体的作用。(C)2003年爱思唯尔公司All rights reserved.
The tripartite model of memory proposed the requirement of attentional switching when accessing different items in working memory [J. Exp. Psychol. Learn. Mem. Cogn. 27 (2001) 817]. This internal focus of attention is limited to just one item and the switching process is time-consuming [Mem. Cogn. 26 (1998) 2631].In the current study, given a three-digit list stored in working memory, we found that it took longer to shift attention in the direction of "Upstream" than "Downstream", and that each shift was a "single step" process. To investigate the neural basis of this type of attention switching, we performed a functional MRI study. The results revealed that at least three important brain areas are involved, including the left dorsal lateral prefrontal cortex, the cingulate gyrus, and the medial occipital cortex. These areas an showed greater activation in the attention shift condition compared to control conditions of no (or decreased) attention shift requirements. In addition, the hemodynamic activities in these areas are highly correlated, suggesting a strong functional connectivity between them. Taken together with evidence from several recent investigations, our results suggest that these areas each play an important and specific role in collaboratively supporting the function of attention shift in working memory. (C) 2003 Elsevier Inc. All rights reserved.