Time-dependent differences in the rat's motor response to amphetamine
Time-dependent differences in the rat's motor response to amphetamine
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DOI：
10.1016/s0091-3057(97)00438-3
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发表时间：
1998-02-01
影响因子：
3.6
通讯作者：
Dafny, N
中科院分区：
文献类型：
--
作者：
Gaytan, O;Swann, A;Dafny, N
使用计算机活动监测系统记录了5种不同的运动行为指数，研究了d-安非他明在大鼠明暗周期开始时给药的剂量相关运动效应。经过7天的适应和2天的基线监测后，将大鼠随机分为无治疗时间对照组（n = 12），或接受0（载体）、0.6；1.25, 2.5，或10 mg/kg d-安非他明（n = 8），分别在第3天的光照期（0800）1小时或黑暗期（2000）1小时进行另外五组。时间控制组在实验期间表现出稳定的基线活动水平。与基线相比，所有剂量（0.6、1.25、2.5和10 mg/kg）在两次给药时均显著提高了运动活动（p < 0.01），但并非所有运动指标都遵循相同的反应模式。在两个注射时间，最大的增加比基线一般发生在1.25 mg/kg剂量的安非他明（p < 0.001）。药物作用的持续时间也随着剂量的增加而增加。高剂量AMP （10 mg/kg）在光期和暗期产生的刻板印象效应不同，但安非他明对运动行为的影响是相同的，而不管活动期之间运动活动基线的差异。(C) 1998爱思唯尔科学有限公司
The dose-related motor effects of d-amphetamine given at the beginning of the light and dark cycle of rats were investigated using a computerized activity-monitoring system that recorded five different motor behavior indices. After 7 days of acclimatization and 2 days of baseline monitoring, rats were randomized into either a no-treatment time control group (n = 12), or to receive 0 (vehicle), 0.6; 1.25, 2.5, or 10 mg/kg d-amphetamine (n = 8 each) either 1 h into the light phase (0800) or another five groups at 1 h into the dark phase (2000) of day 3. The time control group exhibited a stable baseline level of activity for the length of the experiment. All doses (0.6, 1.25, 2.5, and 10 mg/kg) significantly elevated (p < 0.01) locomotor activity compared to baseline at both times of administration, but not all motor indices followed the same pattern of response. At both injection times, the maximum increase over baseline generally occurred following the 1.25 mg/kg dose of amphetamine (p < 0.001). The duration of the drug effect also increased with each dose. The stereotypic effects produced by high doses of AMP (10 mg/kg) was different when applied at the light phase compared to the dark phase, but the amphetamine effect on locomotor behavior remained the same regardless of the difference in motor activity baseline between the activity phases. (C) 1998 Elsevier Science Inc.