Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis
Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis
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DOI：
10.1002/cne.20786
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发表时间：
2005-12-05
影响因子：
2.5
通讯作者：
Lowell, BB
中科院分区：
文献类型：
--
作者：
Elmquist, JK;Coppari, R;Lowell, BB
在过去的十年里，我们对中枢神经系统(CNS)调节食物摄入量和体重的能力有了很大的了解和欣赏。这是由调节体重动态平衡的关键分子的发现带头的。现在也很明显，中枢神经系统，特别是下丘脑，在直接调节葡萄糖稳态方面起着主要作用，与体重的影响无关。鉴于西方社会肥胖症和II型糖尿病的发病率不断上升，这些发现具有重要意义。在这篇文章中，我们将重点介绍转基因小鼠的最新数据。这些数据和其他模型有助于剖析中枢神经系统调节体重和葡萄糖动态平衡的途径。最后，尽管这些研究具有说明性，但它们也强调了我们相对缺乏知识，并强调了需要更明确的方法来揭示这些通路的功能意义。
The past decade has greatly increased our understanding and appreciation of the ability of the central nervous system (CNS) to regulate food intake and body weight. This was spearheaded by the discovery of key molecules regulating body weight homeostasis. It is now also apparent that the CNS, especially the hypothalamus, plays a primary role in directly regulating glucose homeostasis, independently of effects on body weight. These discoveries are important given the increasing incidences of obesity and type II diabetes in Western societies. In this article, we will highlight recent data from genetically modified mice. These data and other models have helped to dissect the CNS pathways regulating body weight and glucose homeostasis. Finally, although these studies have been illustrative, they also underscore our relative lack of knowledge and highlight the need for more definitive approaches to unravel the functional significance of these pathways.