Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13.
Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13.
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DOI：
10.1093/infdis/175.1.118
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
T. V. D. Poll;R. D. W. Malefyt;S. Coyle;Stephen F. Lowry
中科院分区：
文献类型：
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作者：
T. V. D. Poll;R. D. W. Malefyt;S. Coyle;Stephen F. Lowry
对42例临床定义的脓毒症患者进行为期3天的随访，并对7名健康人静脉注射内毒素（2 ng/kg）后的血浆可溶性白细胞介素（IL）-1受体II型、IL-10和IL-13浓度进行了测定。脓毒症患者的可溶性IL-1受体II型水平持续高于健康对照组，在所有时间点，死亡患者（n = 22）高于存活患者（n = 20）。IL-10在81%的脓毒症患者的循环中被发现，而在正常血浆中检测不到。在随访期间，IL-10仅在未存活患者中始终保持较高水平，而在存活患者中则显着下降。内毒素诱导IL-10，而可溶性IL-1受体II型保持不变。IL-13在绝大多数患者中仍然检测不到，并且不是由内毒素诱导的。增强的IL-13产生似乎不是脓毒症期间诱导型宿主防御机制的一部分。
Plasma concentrations of soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13 were measured in 42 patients with clinically defined sepsis during a 3-day follow-up and in 7 healthy humans after intravenous injection of endotoxin (2 ng/kg). Levels of soluble IL-1 receptor type II were persistently elevated in patients with sepsis than in healthy controls and higher in nonsurviving patients (n = 22) than in surviving patients (n = 20) at all time points. IL-10 was found in the circulation of 81% of patients with sepsis, while it was not detectable in normal plasma. During follow-up, IL-10 remained invariably high only in nonsurviving patients, while it significantly decreased in survivors. Endotoxin induced IL-10, while soluble IL-1 receptor type II remained unchanged. IL-13 remained undetectable in the vast majority of patients and was not induced by endotoxin. Enhanced IL-13 production does not seem to be part of an inducible host defense mechanism during sepsis.