Prevention of graft rejection following bone marrow transplantation
Prevention of graft rejection following bone marrow transplantation
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骨髓移植后移植物排斥反应的预防
DOI：
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
M. Cline
中科院分区：
文献类型：
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作者：
R. Gale;W. Ho;S. Feig;R. Champlin;A. Tesler;E. Arenson;S. Ladish;L. Young;D. Winston;R. Sparkes;J. Fitchen;M. Territo;G. Sarna;L. Wong;Y. Paik;Y. Bryson;D. Golde;J. Fahey;M. Cline
来自hla相同同胞的骨髓移植越来越多地用于治疗严重再生障碍性贫血。这种方法的一个主要问题是移植排斥反应发生在25%-60%的环磷酰胺移植患者中。在大多数移植中心，很难准确地识别出移植物排斥反应高风险的患者。我们研究了环磷酰胺（200mg / kg）和低剂量全身照射（3gy；相当于300 rad）对23例连续未选择的再生障碍性贫血患者至少6个月的调节方案。只有一次移植排斥反应。移植物抗宿主病和间质性肺炎不因更密集的调理方案而增加。精算生存率为1年61%，2.5年49%。环磷酰胺和低剂量全身照射是再生障碍性贫血患者的有效调理方案。在大多数移植中心无法获得准确预测移植排斥反应的测试时，它可能特别有用。
Bone marrow transplantation from an HLA-identical sibling is increasingly used in the treatment of severe aplastic anemia. One major problem with this approach is graft rejection that occurs in 25%-60% of patients conditioned for transplantation with cyclophosphamide. At most transplant centers it has been difficult to accurately identify patients at high risk for graft rejection. We studied a conditioning regimen of cyclophosphamide (200 mg per kg) and low-dose total body irradiation (3 Gy; equivalent to 300 rad) in 23 consecutive unselected patients with aplastic anemia followed for a minimum of 6 mo. There was only one episode of graft rejection. Graft-versus-host disease and interstitial pneumonitis were not increased by the more intensive conditioning regimen. Actuarial survival was 61% at 1 yr and 49% at 2.5 yr. Cyclophosphamide and low-dose total body irradiation is an effective conditioning regimen in patients with aplastic anemia. It may be particularly useful when accurate predictive tests of graft rejection are not available as is the case in most transplant centers.
急性白血病的骨髓移植。
影响因子：
3.6
作者：
Santos,GW;Kaizer,H
通讯作者：
Kaizer,H