Risk Factors and Incidence of Epilepsy after Severe Traumatic Brain Injury.
Risk Factors and Incidence of Epilepsy after Severe Traumatic Brain Injury.
复制标题
严重创伤性脑损伤后癫痫的危险因素和发病率。
DOI：
10.1002/ana.26443
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发表时间：
2022-10
影响因子：
11.2
通讯作者：
Elmer, Jonathan
中科院分区：
文献类型：
--
作者：
Pease, Matthew;Gonzalez-Martinez, Jorge;Puccio, Ava;Nwachuku, Enyinna;Castellano, James F.;Okonkwo, David O.;Elmer, Jonathan
We determined incidence of post-traumatic epilepsy (PTE) after severe traumatic brain injury (TBI). Of 392 patients surviving to discharge, cumulative incidence of PTE was 25% at five years and 32% at fifteen years, an increase compared to historical reports. Among patients with one late seizure (>7 days post-trauma), risk of seizure recurrence was 62% after one year and 82% at ten years. Competing hazards regression identified age, decompressive hemicraniectomy, and intracranial infection as independent predictors of PTE. Patients with severe TBI and a single late post-traumatic seizure will likely require long-term antiseizure medicines.
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