Direct Ruthenium-Catalyzed Hydrogenation of Carboxylic Acids to Alcohols
Direct Ruthenium-Catalyzed Hydrogenation of Carboxylic Acids to Alcohols
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DOI：
10.1002/anie.201503562
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发表时间：
2015-09-01
影响因子：
16.6
通讯作者：
Beller, Matthias
中科院分区：
文献类型：
--
作者：
Cui, Xinjiang;Li, Yuehui;Beller, Matthias
羧酸到醇的绿色还原是有机化学中的一项具有挑战性的任务。在这里，我们描述了通过羧酸催化氢化生成醇的通用方案。成功的关键是结合使用 Ru(acac)(3)、三磷和路易斯酸。该新方法显示出广泛的底物耐受性，并且可以顺利地还原包括生物质衍生化合物在内的多种脂肪族羧酸。
The green reduction of carboxylic acids to alcohols is a challenging task in organic chemistry. Herein, we describe a general protocol for generation of alcohols by catalytic hydrogenation of carboxylic acids. Key to success is the use of a combination of Ru(acac)(3), triphos and Lewis acids. The novel method showed broad substrate tolerance and a variety of aliphatic carboxylic acids including biomass-derived compounds can be smoothly reduced.