Signaling Pathways that Control Cell Proliferation
Signaling Pathways that Control Cell Proliferation
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DOI：
10.1101/cshperspect.a008904
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发表时间：
2013-03-01
影响因子：
7.2
通讯作者：
Xiong, Yue
中科院分区：
文献类型：
--
作者：
Duronio, Robert J.;Xiong, Yue
细胞决定增殖或保持静止使用的信号通路，连接信息的细胞环境的G（1）期的细胞周期。通过G（1）期的进展由pRB蛋白控制，其功能是抑制退出有丝分裂的细胞和静止细胞中E2F转录因子的活性。通过G（1）细胞周期蛋白依赖性激酶（CDK）磷酸化pRB蛋白释放E2F因子，促进向S期的转变。CDK活性主要通过CDK催化亚基与细胞周期蛋白伴侣和CDK抑制剂的结合来调节。因此，促有丝分裂和抗增殖信号通过细胞周期蛋白和CDK抑制剂的转录调节和泛素依赖性降解对细胞增殖发挥作用。
Cells decide to proliferate or remain quiescent using signaling pathways that link information about the cellular environment to the G(1) phase of the cell cycle. Progression through G(1) phase is controlled by pRB proteins, which function to repress the activity of E2F transcription factors in cells exiting mitosis and in quiescent cells. Phosphorylation of pRB proteins by the G(1) cyclin-dependent kinases (CDKs) releases E2F factors, promoting the transition to S phase. CDK activity is primarily regulated by the binding of CDK catalytic subunits to cyclin partners and CDK inhibitors. Consequently, both mitogenic and antiproliferative signals exert their effects on cell proliferation through the transcriptional regulation and ubiquitin-dependent degradation of cyclins and CDK inhibitors.