The 2005 Dietary Guidelines for Americans and risk of the metabolic syndrome
The 2005 Dietary Guidelines for Americans and risk of the metabolic syndrome
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DOI：
10.1093/ajcn/86.4.1193
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发表时间：
2007-10-01
影响因子：
7.1
通讯作者：
Jacques, Paul F.
中科院分区：
文献类型：
--
作者：
Fogli-Cawley, Jeanene J.;Dwyer, Johanna T.;Jacques, Paul F.
背景资料：2005年美国人膳食指南指数（DGAI）是为了评估2005年美国人膳食指南（DGA）中关于慢性病风险的饮食建议的遵守情况而创建的。目的：目的是评估与2005年DGA一致的饮食模式之间的关系，如DGAI所测量的，以及代谢综合征（MetS）的患病率和个体MetS风险因素。设计图：DGAI评分和代谢综合征的代谢危险因素进行了评估，在一项横断面研究的3177名参与者从心脏研究后代队列。MetS是根据国家胆固醇教育计划成人治疗小组III标准定义的。校正潜在混杂因素后，DGAI评分与腰围呈负相关（趋势P < 0.001），三酰甘油浓度（趋势P = 0.005），均为舒张压（趋势P = 0.002）和收缩压（趋势P = 0.01）、腹部肥胖（趋势P < 0.001）和高血糖（趋势P = 0.03）的患病率。当排除因任何风险因素接受治疗的患者时，DGAI最高五分位数类别中的个体MetS患病率显著低于最低类别中的个体（比值比：0.64; 95%CI：0.47，0.88;趋势P = 0.005）。DGAI评分和年龄之间存在显著的相互作用; DGAI评分和代谢综合征之间的关联主要限于55岁以下的成年人（比值比：0.57; 95%CI：0.36，0.92;趋势P < 0.01）。结论：与2005年DGA一致的饮食模式与代谢综合征（CVD的潜在危险因素）的患病率较低相关。
Background: The 2005 Dietary Guidelines for Americans index (DGAI) was created to assess adherence to the dietary recommendations of the 2005 Dietary Guidelines for Americans (DGA) in relation to chronic disease risk.Objective: The objective was to assess the relation between dietary patterns consistent with the 2005 DGA as measured by the DGAI and both the prevalence of the metabolic syndrome (MetS) and individual MetS risk factors. Design: DGAI scores and metabolic risk factors for MetS were assessed in a cross-sectional study of 3177 participants from the Framingham Heart Study Offspring Cohort. MetS was defined on the basis of the National Cholesterol Education Program Adult Treatment Panel III criteria.Results: After adjustment for potential confounders, the DGAI score was inversely related to waist circumference (P for trend < 0.001), triacylglycerol concentration (P for trend = 0.005), both diastolic (P for trend = 0.002) and systolic (P for trend = 0.01) blood pressure, the prevalence of abdominal adiposity (P for trend < 0.001), and hyperglycemia (P for trend = 0.03). The prevalence of MetS was significantly lower in individuals in the highest DGAI quintile category than in those in the lowest category (odds ratio: 0.64; 95% CI: 0.47, 0.88; P for trend = 0.005) when those being treated for any of the risk factors were excluded. There was a significant interaction between DGAI score and age; the association between the DGAI score and MetS was confined largely to adults younger than 55 y (odds ratio: 0.57; 95% CI: 0.36, 0.92; P for trend < 0.01).Conclusions: A dietary pattern consistent with the 2005 DGA was associated with a lower prevalence of MetS-a potential risk factor for CVD.