Set- and code-specific activation in the frontal cortex: An fMRI study of encoding and retrieval of faces and words
Set- and code-specific activation in the frontal cortex: An fMRI study of encoding and retrieval of faces and words
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DOI：
10.1162/089892999563698
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发表时间：
1999-11-01
影响因子：
3.2
通讯作者：
Sanders, AL
中科院分区：
文献类型：
--
作者：
McDermott, KB;Buckner, RL;Sanders, AL
额叶皮层被描述为在人类记忆处理中扮演“特定集合”和“特定代码”角色。集合特异性是指发现激活模式中面向目标的差异（例如，相对于检索的编码）。代码特异性是指针对不同类型的刺激（例如言语/非言语）发现不同的激活模式。使用两个（代码：语言，非语言）乘两个（集合：编码，检索）受试者内设计和功能磁共振成像，我们探索了代码类型和心理设置对额叶皮层两个区域的影响，这两个区域之前已被证明与记忆有关。额下回背侧区域 (BA 6/44) 表现出代码特异性效应。具体来说，获得了材料类型与半球的相互作用，使得单词主要产生左侧激活，而不熟悉的面孔主要引起右侧激活。右额叶极皮层（BA 10）附近的一个区域在许多记忆检索研究中都被激活，显示出特定的激活，因为它在检索过程中比编码过程中更活跃。这些数据表明，额叶皮层中的不同区域以系统但不同的方式对人类记忆处理做出了贡献。
The frontal cortex has been described as playing both "set-specific" and "code-specific" roles in human memory processing. Set specificity refers to the finding of goal-oriented differences in activation patterns (e.g., encoding relative to retrieval). Code specificity refers to the finding of different patterns of activation for different types of stimuli (e.g., verbal/nonverbal). Using a two (code: verbal, nonverbal) by two (set: encoding, retrieval) within-subjects design and fMRI, we explored the influence of type of code and mental set in two regions in the frontal cortex that have been previously shown to be involved in memory. A region in the dorsal extent of the inferior frontal gyrus (BA 6/44) demonstrated code-specific effects. Specifically, an interaction of material type with hemisphere was obtained, such that words produced predominantly left-lateralized activation, whereas unfamiliar faces elicited predominantly right-lateralized activation. A region of the right frontal polar cortex tin or near BA 10), which has been activated in many memory retrieval studies, showed set-specific activation in that it was more active during retrieval than encoding. These data demonstrate that distinct regions in the frontal cortex contribute in systematic yet different ways to human memory processing.