The impact of local population genetic background on the spread of the selfish element Medea-1 in red flour beetles.
The impact of local population genetic background on the spread of the selfish element Medea-1 in red flour beetles.
复制标题
当地群体遗传背景对自私元素Medea-1在红粉甲虫中传播的影响。
DOI：
10.1002/ece3.5946
复制
发表时间：
2020
影响因子：
2.6
通讯作者：
Gould,Fred
中科院分区：
文献类型：
--
作者：
Cash,SarahA;Robert,MichaelA;Lorenzen,MarcéD;Gould,Fred
在许多物种的基因组中发现了自私的遗传因素，但我们对它们的进化动力学的理解只是部分理解。赤拟谷盗（Tribolium castaneum）的许多种群中天然存在许多不同的中自私元素。尽管模型预测这些美狄亚元素在种群中的频率会增加，因为携带美狄亚的母亲的任何后代如果没有遗传到至少一个美狄亚等位基因，就会死亡，但缺乏证明自然发生的美狄亚元素增加的实验。我们在美国对特定的Medea元素M1进行的调查显示，它在地理上的分布是不均匀的。根据调查，无法确定这种分布是由离散种群的M1定殖的缓慢过程引起的，还是某些种群缺乏M1，因为它们具有赋予对中间机制抗性的遗传因素。我们表明，人口自然低到中间M1频率可能代表瞬态过程中的Medeaspread。此外，我们没有发现任何证据表明遗传因素排除M1从美国人口的元素是目前没有发现的。我们还显示了如何一个已知的抑制因子ofMedeacan损害M1在人口的增加，并讨论了我们的研究结果的影响害虫管理应用的Medeaelements。
Selfish genetic elements have been found in the genomes of many species, yet our understanding of their evolutionary dynamics is only partially understood. A number of distinct selfishMedeaelements are naturally present in many populations of the red flour beetle (Tribolium castaneum). Although theseMedeaelements are predicted by models to increase in frequency within populations because any offspring of aMedea‐bearing mother that do not inherit at least oneMedeaallele will die, experiments demonstrating an increase in a naturally occurringMedeaelement are lacking. Our survey of the specificMedeaelement,M1, in the United States showed that it had a patchy geographic distribution. From the survey, it could not be determined if this distribution was caused by a slow process of M1colonization of discrete populations or if some populations lacked M1because they had genetic factors conferring resistance to theMedeamechanism. We show that populations with naturally low to intermediate M1frequencies likely represent transient states during the process ofMedeaspread. Furthermore, we find no evidence that genetic factors are excluding M1from US populations where the element is not presently found. We also show how a known suppressor ofMedeacan impair the increase of M1in populations and discuss the implications of our findings for pest‐management applications ofMedeaelements.