Integration of chemosensory and hormonal cues is essential for sexual behaviour in the male Syrian hamster: role of the medial amygdaloid nucleus.
Integration of chemosensory and hormonal cues is essential for sexual behaviour in the male Syrian hamster: role of the medial amygdaloid nucleus.
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化学感应和激素线索的整合对于雄性叙利亚仓鼠的性行为至关重要：内侧杏仁核的作用。
DOI：
10.1016/s0306-4522(96)00629-x
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发表时间：
1997
期刊：
影响因子：
3.3
通讯作者：
Coolen,LM
中科院分区：
文献类型：
--
作者：
Wood,RI;Coolen,LM
雄性仓鼠的交配行为需要化学感觉和激素的提示，如果任何一个信号被中断，交配就会被取消。此外，整合化学感觉刺激与类固醇信号是必不可少的交配。在去势的雄性仓鼠中，在视前区植入一个充满睾丸激素的套管可以刺激交配行为。然而，切除同侧嗅球阻止类固醇促进性活动。目前的研究确定了交配行为所需的化学感觉和激素线索的整合是否分布在大脑的类固醇敏感核内，或者仅限于视前区。具体来说，假设进行了测试，内侧杏仁核是能够气味和激素的整合。去势的雄性仓鼠接受了在内侧杏仁核中的睾酮脑内植入，并切除植入物同侧或对侧的单个嗅球。在同侧或对侧球切除雄性中，植入手术和球切除术后交配行为没有增加。在第二项研究中，男性在植入手术后三周进行球切除术，以证明内侧杏仁核中的睾酮刺激男性性行为的能力，以及球切除术后的行为丧失。结果证实，气味和类固醇线索的整合是必不可少的交配在雄性仓鼠。此外，内侧杏仁核有助于化学感觉和激素的整合。然而，与类固醇刺激的视前区相比，内侧杏仁核中的睾酮的行为效应对嗅觉系统的操纵更敏感，这表明杏仁核需要双侧化学感觉输入。
Mating behaviour in the male hamster requires chemosensory and hormonal cues, and copulation is abolished if either signal is interrupted. In addition, the integration of chemosensory stimuli with steroid signals is essential for mating. In castrated male hamsters, implantation of a testosterone-filled cannula in the preoptic area stimulates mating behaviour. However, removal of the ipsilateral olfactory bulb prevents steroid facilitation of sexual activity. The present studies determined if the integration of chemosensory and hormonal cues necessary for mating behaviour is distributed within steroid-sensitive nuclei in the brain, or is restricted to the preoptic area. Specifically, the hypothesis was tested that the medial amygdala is capable of odour and hormone integration. Castrated male hamsters received an intracerebral implant of testosterone in the medial amygdala combined with removal of a single olfactory bulb, ipsilateral or contralateral to the implant. Mating behaviour did not increase after implant surgery and bulbectomy in either ipsilateral or contralateral bulbectomized males. In a second study, males were bulbectomized three weeks after implant surgery, to demonstrate the ability of testosterone in the medial amygdala to stimulate male sexual behaviour, and the loss of behaviour following bulbectomy. The results confirm that integration of odour and steroid cues is essential for mating in the male hamster. Moreover, the medial amygdaloid nucleus contributes to chemosensory and hormonal integration. However, compared with steroid stimulation in the preoptic area, the behavioural effects of testosterone in the medial amygdaloid nucleus are more sensitive to manipulations of the olfactory system, suggesting that the amygdala requires bilateral chemosensory input.